B6;129P2-Dp(16Hspa13-App)2Yah/Orl

Status	Available to order
EMMA ID	EM:02101
International strain name	B6;129P2-Dp(16Hspa13-App)2Yah/Orl
Alternative name	Dup(Stch-App)Ts2Yah
Strain type	Targeted Mutant Strains : Other targeted
Allele/Transgene symbol	Dp(16Hspa13-App)2Yah,
Gene/Transgene symbol	Dp(16Hspa13-App)2Yah

Information from provider

Provider	Yann HERAULT
Provider affiliation	TAAM-CDTA UPS44, Institut de Transgenose, INTRAGENE
Genetic information	Duplication of the region between the Hspa13 (Stch) and App genes engineered using MICER in HM-1 ES cells.
Phenotypic information	Heterozygotes: no major defects.
Breeding history	Duplication generated in 129P2 HM-1 ES cells. Cells injected in C57BL/6 blastocysts. Backcross on C57BL/6.
References	Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.;Brault Véronique, Duchon Arnaud, Romestaing Caroline, Sahun Ignasi, Pothion Stéphanie, Karout Mona, Borel Christelle, Dembele Doulaye, Bizot Jean-Charles, Messaddeq Nadia, Sharp Andrew J, Roussel Damien, Antonarakis Stylianos E, Dierssen Mara, Hérault Yann, ;2015;PLoS genetics;11;e1005062; 25803843 Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

Down syndrome / DOID:14250

Literature references

Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.;Brault Véronique, Duchon Arnaud, Romestaing Caroline, Sahun Ignasi, Pothion Stéphanie, Karout Mona, Borel Christelle, Dembele Doulaye, Bizot Jean-Charles, Messaddeq Nadia, Sharp Andrew J, Roussel Damien, Antonarakis Stylianos E, Dierssen Mara, Hérault Yann, ;2015;PLoS genetics;11;e1005062; 25803843
Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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