STOCK Igh-8tm2.1Aak/Orl

Status

Available to order

EMMA IDEM:02109
International strain nameSTOCK Igh-8tm2.1Aak/Orl
Alternative namepAp-gamma3
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolIgh-8tm2.1Aak,
Gene/Transgene symbolIgh-8

Information from provider

ProviderAhmed Amine Khamlichi
Provider affiliationCNRS UMR 6101
Genetic informationTargeting construct is derived from 129 DNA. The insertion brings polyadenylation and pause sites upstream of Sgamma3 region. All elements have been left intact.
Phenotypic informationInhibition of germline transcription elongation. A specific defect in class switching to IgG3.
Breeding historyBred with C57BL/6 for several generations.
References
  • Sense transcription through the S region is essential for immunoglobulin class switch recombination.;Haddad Dania, Oruc Zéliha, Puget Nadine, Laviolette-Malirat Nathalie, Philippe Magali, Carrion Claire, Le Bert Marc, Khamlichi Ahmed Amine, ;2011;The EMBO journal;30;1608-20; 21378751

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • immune system phenotype / MGI

Literature references

  • Sense transcription through the S region is essential for immunoglobulin class switch recombination.;Haddad Dania, Oruc Zéliha, Puget Nadine, Laviolette-Malirat Nathalie, Philippe Magali, Carrion Claire, Le Bert Marc, Khamlichi Ahmed Amine, ;2011;The EMBO journal;30;1608-20; 21378751

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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