B6.129P2-Creb1tm3Gsc/Ieg
| Status | Available to order |
| EMMA ID | EM:02151 |
| International strain name | B6.129P2-Creb1tm3Gsc/Ieg |
| Alternative name | CREB flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Creb1tm3Gsc, |
| Gene/Transgene symbol | Creb1 |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | Exon 10 of the Creb1 gene, encoding the first part of the bZIP domain, was flanked by loxP sites. |
| Phenotypic information | None. |
| Breeding history | Backcrossed with C57BL/6 genetic background for more than 10 generations. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Literature references
- Disruption of CREB function in brain leads to neurodegeneration.;Mantamadiotis Theo, Lemberger Thomas, Bleckmann Susanne C, Kern Heidrun, Kretz Oliver, Martin Villalba Ana, Tronche François, Kellendonk Christoph, Gau Daniel, Kapfhammer Josef, Otto Christiane, Schmid Wolfgang, Schütz Günther, ;2002;Nature genetics;31;47-54; 11967539
- A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction.;Fusco Salvatore, Ripoli Cristian, Podda Maria Vittoria, Ranieri Sofia Chiatamone, Leone Lucia, Toietta Gabriele, McBurney Michael W, Schütz Günther, Riccio Antonella, Grassi Claudio, Galeotti Tommaso, Pani Giovambattista, ;2012;Proceedings of the National Academy of Sciences of the United States of America;109;621-6; 22190495