B6.Cg-Tg(Ins2-CD80)3B7Flv/Orl

Status	Available to order
EMMA ID	EM:00216
International strain name	B6.Cg-Tg(Ins2-CD80)3B7Flv/Orl
Alternative name	RIP-B7
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Ins2-CD80)3B7Flv,
Gene/Transgene symbol	Tg(Ins2-CD80)3B7Flv

Information from provider

Provider	Sylvie Guerder
Provider affiliation	U136, CIML
Phenotypic information	Transgenic expression of human CD80 (B7-1) specifically in the pancreatic beta cells. Increased susceptibility to type 1 diabetes. Increased susceptibility to immune system-mediated diabetes.
References	Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes.;Guerder S, Eynon E E, Flavell R A, ;1998;Journal of immunology (Baltimore, Md. : 1950);161;2128-40; 9725204 Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.;Wong S, Guerder S, Visintin I, Reich E P, Swenson K E, Flavell R A, Janeway C A, ;1995;Diabetes;44;326-9; 7533734

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

type 1 diabetes mellitus / DOID:9744

Literature references

Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes.;Guerder S, Eynon E E, Flavell R A, ;1998;Journal of immunology (Baltimore, Md. : 1950);161;2128-40; 9725204
Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.;Wong S, Guerder S, Visintin I, Reich E P, Swenson K E, Flavell R A, Janeway C A, ;1995;Diabetes;44;326-9; 7533734

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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