C3H101H-Col3a1Tsk2/H

Status

Available to order

EMMA IDEM:02195
International strain nameC3H101H-Col3a1Tsk2/H
Alternative nameTsk2
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCol3a1Tsk2,
Gene/Transgene symbolCol3a1

Information from provider

ProviderJo Peters
Provider affiliationInstitute of Hearing Research, MRC (Medical Research Council)
Phenotypic informationHomozygotes probably die prenatally. Heterozygotes can be recognized at 1 to 2 weeks of age by tightness of the skin over the shoulders when picked up. No other abnormality was detected and the mice are fully viable and fertile. Histological examination of the skin of these mice reveals accumulation of collagen and mononuclear cell infiltration in dermis and adipose tissue. An increased collagen content is found biochemically, and steady-state levels of Col1a1 mRNA.
References
  • The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.;Long Kristen B, Li Zhenghui, Burgwin Chelsea M, Choe Susanna G, Martyanov Viktor, Sassi-Gaha Sihem, Earl Josh P, Eutsey Rory A, Ahmed Azad, Ehrlich Garth D, Artlett Carol M, Whitfield Michael L, Blankenhorn Elizabeth P, ;2015;The Journal of investigative dermatology;135;718-27; 25330296
  • Tight skin-2 (Tsk-2);Peters J, Ball ST;1986;Mouse News Lett.;74;91-2;

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • tight skin / MGI
  • thick dermal layer / MGI
  • abnormal skin morphology / MGI
  • skin inflammation / MGI
  • cellular phenotype / MGI
  • skin fibrosis / MGI
  • adipose tissue inflammation / MGI
  • prenatal lethality, complete penetrance / MGI

Literature references

  • The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.;Long Kristen B, Li Zhenghui, Burgwin Chelsea M, Choe Susanna G, Martyanov Viktor, Sassi-Gaha Sihem, Earl Josh P, Eutsey Rory A, Ahmed Azad, Ehrlich Garth D, Artlett Carol M, Whitfield Michael L, Blankenhorn Elizabeth P, ;2015;The Journal of investigative dermatology;135;718-27; 25330296
  • Tight skin-2 (Tsk-2);Peters J, Ball ST;1986;Mouse News Lett.;74;91-2;

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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