B6;SJL-Plekha5Tg(AMH-cre)1Flor/Orl
Status | Available to order |
EMMA ID | EM:00022 |
International strain name | B6;SJL-Plekha5Tg(AMH-cre)1Flor/Orl |
Alternative name | AMH-Cre |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Plekha5Tg(AMH-cre)1Flor, |
Gene/Transgene symbol | Plekha5 |
Information from provider
Provider | Florian GUILLOU |
Provider affiliation | INRA, INRA |
Genetic information | A 3.6 Kbp EcoRI/AvrII fragment of the human anti-Mullerian hormone (AMH, or Mullerian inhibitor substance, MIS) gene promoter was inserted upstream of the cre recombinase gene with the metallothionein I polyadenylation signal. The cre gene contains a T to G transversion in the -3 position, relative to the AUG translation start, that increases the translational proficiency of the cre transcript. The insertion site of the original cre transgene has then been mapped to intron 3 of the Plekha5 gene. |
Phenotypic information | This line has a scientific interest for conditional gene knock-out in Sertoli cells and granulosa cells. |
Breeding history | 2 backcrosses to C57BL/6. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice.;Lécureuil Charlotte, Fontaine Isabelle, Crepieux Pascale, Guillou Florian, ;2002;Genesis (New York, N.Y. : 2000);33;114-8; 12124943
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