B6.Cg-Tyrc-Brd Mir155tm1.1Brd/H

Status

Available to order

EMMA IDEM:02231
International strain nameB6.Cg-Tyrc-Brd Mir155tm1.1Brd/H
Alternative nameBIC
Strain typeSpontaneous
Allele/Transgene symbolTyrc-Brd,
Gene/Transgene symbolTyr

Information from provider

ProviderAllan Bradley
Provider affiliationWellcome Trust Sanger Institute
Genetic informationTargeted Deletion of microRNA-155 (aka Bic) by homologous recombination in ES cells using a gene replacement vector. The vector contained a floxed PGK-Neo selection cassette. Mice were obtained and then crossed to CMV-cre recombinase-deleter line to remove the PGK-Neo cassette.
Phenotypic informationImmune-deficient mice. This mutation is on a C57BL/6-Tyrc-Brd/c-Brd background and is albino in appearance. The BIC mice (EMMA ID EM:02231) have been backcrossed at least 5 times to C57BL/6, thus making them suitable for bone marrow transplantation, without rejection, to any C57BL/6 mice, regardless of coat color.
Breeding historyBackcrossed at least 5 times to C57BL/6
References
  • Requirement of bic/microRNA-155 for normal immune function.;Rodriguez Antony, Vigorito Elena, Clare Simon, Warren Madhuri V, Couttet Philippe, Soond Dalya R, van Dongen Stijn, Grocock Russell J, Das Partha P, Miska Eric A, Vetrie David, Okkenhaug Klaus, Enright Anton J, Dougan Gordon, Turner Martin, Bradley Allan, ;2007;Science (New York, N.Y.);316;608-11; 17463290

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased T-helper 2 cell number / MGI
  • decreased IgG1 level / MGI
  • decreased regulatory T cell number / MGI
  • absent skin pigmentation / MGI
  • absent coat pigmentation / MGI
  • decreased eye pigmentation / MGI

Literature references

  • Requirement of bic/microRNA-155 for normal immune function.;Rodriguez Antony, Vigorito Elena, Clare Simon, Warren Madhuri V, Couttet Philippe, Soond Dalya R, van Dongen Stijn, Grocock Russell J, Das Partha P, Miska Eric A, Vetrie David, Okkenhaug Klaus, Enright Anton J, Dougan Gordon, Turner Martin, Bradley Allan, ;2007;Science (New York, N.Y.);316;608-11; 17463290

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).