B6;129S5-Acsl3Gt(OST148301)Lex/Orl

Status

Available to order

EMMA IDEM:02308
International strain nameB6;129S5-Acsl3Gt(OST148301)Lex/Orl
Alternative nameLEXKO-011
Strain typeGene-trap
Allele/Transgene symbolAcsl3Gt(OST148301)Lex,
Gene/Transgene symbolAcsl3

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationThe homozygous mutant mice exhibited increased peripheral blood percentages of CD4 cells and decreased B cells when compared with their wild-type littermates and the historical means. Decreased IgG1 response to ovalbumin was noted in (-/-) mice. In addition, the male mutants exhibited signs of growth retardation, including decreased mean body weight and length, total tissue mass, and lean body mass. RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice.
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased body length / MGI
  • decreased body weight / MGI
  • postnatal growth retardation / MGI
  • abnormal humoral immune response / MGI
  • abnormal postnatal growth/weight/body size / MGI
  • decreased lean body mass / MGI
  • decreased B cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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