B6;129-Gt(ROSA)26Sortm2(icre/ERT2)Jphe/Orl
| Status | Available to order |
| EMMA ID | EM:02417 |
| International strain name | B6;129-Gt(ROSA)26Sortm2(icre/ERT2)Jphe/Orl |
| Alternative name | Cre2ERT2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gt(ROSA)26Sortm2(icre/ERT2)Jphe, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | Jean-Paul Herman |
| Provider affiliation | CNRS - Université de la Méditerranée |
| Genetic information | The Cre2ERT2 strain is a conditional deleter strain. Cre2ERT2 (ERT2-icre-ERT2) encodes the cre recombinase protein with the ligand binding domain of estrogen receptor fused to its N- and C-terminal end cre expression is inducible by tamoxifen. The coding sequence for Cre2ERT2 has been knocked into the Gt(ROSA)26Sor locus and is under the control of the Gt(ROSA)26Sor promoter. |
| Phenotypic information | None observed. |
| Breeding history | F1 animals were backcrossed to C57BL/6 animals for two generations and inbred thereafter to obtain homozygous animals. They are presently inbred. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Literature references
- ER-based double iCre fusion protein allows partial recombination in forebrain.;Casanova Emilio, Fehsenfeld Sandra, Lemberger Thomas, Shimshek Derya R, Sprengel Rolf, Mantamadiotis Theo, ;2002;Genesis (New York, N.Y. : 2000);34;208-14; 12395386
- Use of ERT2-iCre-ERT2 for conditional transgenesis.;Jullien Nicolas, Goddard Isabelle, Selmi-Ruby Samia, Fina Jean-Luc, Cremer Harold, Herman Jean-Paul, ;2008;Genesis (New York, N.Y. : 2000);46;193-9; 18395834