B6.DDD1-plt/Orl
| Status | Available to order |
| EMMA ID | EM:02423 |
| International strain name | B6.DDD1-plt/Orl |
| Alternative name | paucity of lymph node T cells (plt) |
| Strain type | Spontaneous |
| Allele/Transgene symbol | plt, |
| Gene/Transgene symbol | plt |
Information from provider
| Provider | Hideki Nakano |
| Provider affiliation | National Institute of Environmental Health Science |
| Genetic information | Ccl19 and Ccl21a (also called Ccl21-ser) genes are deleted. |
| Phenotypic information | Migration of Ccr7+ leukocytes including T cells and dendritic cells from blood or peripheral tissues to lymphoid organs is severely impaired in plt/plt mice. |
| Breeding history | DDD/1-plt mice were backcrossed to C57BL/6 mice for 10 generations in Toho University, Japan; plt mice on C57BL/6 background have been maintained by inbreeding. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.;Nakano H, Gunn M D, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;361-9; 11123313
- A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4.;Nakano H, Mori S, Yonekawa H, Nariuchi H, Matsuzawa A, Kakiuchi T, ;1998;Blood;91;2886-95; 9531599
- Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization.;Gunn M D, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams L T, Nakano H, ;1999;The Journal of experimental medicine;189;451-60; 9927507