CBy.Cg-Cd44tm1.1Ugu Tg(DO11.10)10Dlo/Cnrm
Status | Available to order |
EMMA ID | EM:02427 |
International strain name | CBy.Cg-Cd44tm1.1Ugu Tg(DO11.10)10Dlo/Cnrm |
Alternative name | BALB/cByJIco DO11.10 CD44v6v7-/- |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(DO11.10)10Dlo, |
Gene/Transgene symbol | Tg(DO11.10)10Dlo |
Information from provider
Provider | Ursula Günthert |
Provider affiliation | Institut für Pathologie, University of Basel |
Genetic information | A loxP site was inserted 3' of exon v6 and a neomycin resistance cassette, with a 5' loxP site, was inserted 5' of exon v6 of the Cd44 gene. During insertion, 1.6 kb of sequence was lost in the exon v7 region; cre recombinase was transiently expressed in ES cells allowing the removal of neomycin cassette and exon v6. Mice lack both exon v6 and v7. The DO11.10 transgenic line was generated by oocyte injection of a cDNA encoding the T cell receptor DO11.10, reactive to the chicken ovalbumin peptide 323-339. |
Phenotypic information | DO11.10: Expresses transgenic TCR that recognizes chicken ovalbumin in the context of I-Ad (class II restricted). Cd44v6v7-/-. Strongly reduced symptoms in autoimmune diseases and haemopoiesis. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).;Wittig B M, Johansson B, Zöller M, Schwärzler C, Günthert U, ;2000;The Journal of experimental medicine;191;2053-64; 10859330
- Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.;Murphy K M, Heimberger A B, Loh D Y, ;1990;Science (New York, N.Y.);250;1720-3; 2125367
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