B6N.129-Pkd2tm1Dwo/Cnrm

Status

Available to order

EMMA IDEM:02475
International strain nameB6N.129-Pkd2tm1Dwo/Cnrm
Alternative nameB6N-Pkd2LacZ (Pkd2)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPkd2tm1Dwo,
Gene/Transgene symbolPkd2

Information from provider

ProviderBernd Dworniczak
Provider affiliationUniversity Clinics Muenster
Genetic informationExon 1 and a portion of intron 1 were replaced with a cassette containing lacZ and PGK-neo. Transcript was undetected in homozygous mutant embryos at E16.5 by Northern blot analysis.
Phenotypic informationHomozygous mutants: prenatal lethal, whole body edema and focal bleedings; cardiovascular defects include septation, the outflow tract, trabecularization, and the formation of the myocardial wall; heterotaxy; cyst development in pancreas and kidney.
Breeding historyBackcrossed to C57BL/6N, 14th generation.
References
  • The ion channel polycystin-2 is required for left-right axis determination in mice.;Pennekamp Petra, Karcher Christina, Fischer Anja, Schweickert Axel, Skryabin Boris, Horst Jürgen, Blum Martin, Dworniczak Bernd, ;2002;Current biology : CB;12;938-43; 12062060
  • Characterization of the murine polycystic kidney disease (Pkd2) gene.;Pennekamp P, Bogdanova N, Wilda M, Markoff A, Hameister H, Horst J, Dworniczak B, ;1998;Mammalian genome : official journal of the International Mammalian Genome Society;9;749-52; 9716661
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal heart development / MGI
  • abnormal heart looping / MGI
  • kidney cortex cysts / MGI
  • abnormal liver development / MGI
  • absent spleen / MGI
  • abnormal lung development / MGI
  • abnormal left-right axis patterning / MGI
  • hemorrhage / MGI
  • abnormal pancreas morphology / MGI
  • hydrops fetalis / MGI
  • situs inversus / MGI
  • situs ambiguus / MGI
  • pancreas cysts / MGI
  • kidney cysts / MGI
  • abnormal direction of embryo turning / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Literature references

  • The ion channel polycystin-2 is required for left-right axis determination in mice.;Pennekamp Petra, Karcher Christina, Fischer Anja, Schweickert Axel, Skryabin Boris, Horst Jürgen, Blum Martin, Dworniczak Bernd, ;2002;Current biology : CB;12;938-43; 12062060
  • Characterization of the murine polycystic kidney disease (Pkd2) gene.;Pennekamp P, Bogdanova N, Wilda M, Markoff A, Hameister H, Horst J, Dworniczak B, ;1998;Mammalian genome : official journal of the International Mammalian Genome Society;9;749-52; 9716661

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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