CAnN.129S7(B6)-Il1r1tm1Imx/NickH

Status

Available to order

EMMA IDEM:02496
International strain nameCAnN.129S7(B6)-Il1r1tm1Imx/NickH
Alternative nameBALB/cAnNHsd Il1r1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIl1r1tm1Imx,
Gene/Transgene symbolIl1r1

Information from provider

ProviderMartin Nicklin
Provider affiliationSchool of Medicine, University of Sheffield
Additional ownerDr. Jacques Peschon, Institute of Systems Biology, Seattle WA, USA
Genetic informationN10 introgression of Il1r1tm1Imx into BALB/cAnNHsd.
Phenotypic informationThe mice are deficient in the only functional receptor for interleukin-1.
Breeding historyReceived B6-Il1r1tm1Imx from Immunex. Rederived to barrier and backcrossed 11 gen. to BALB/cAnN.
References
  • Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.;Glaccum M B, Stocking K L, Charrier K, Smith J L, Willis C R, Maliszewski C, Livingston D J, Peschon J J, Morrissey P J, ;1997;Journal of immunology (Baltimore, Md. : 1950);159;3364-71; 9317135
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous BALB/cAnN
Breeding at archiving centreMales were archived by sperm freezing on arrival. No breeding was performed at the archiving centre.

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased body length / MGI
  • increased body weight / MGI
  • weight loss / MGI
  • decreased anxiety-related response / MGI
  • hypoactivity / MGI
  • increased circulating insulin level / MGI
  • abnormal nervous system electrophysiology / MGI
  • increased susceptibility to bacterial infection / MGI
  • enhanced wound healing / MGI
  • increased growth rate / MGI
  • increased liver weight / MGI
  • increased susceptibility to age related obesity / MGI
  • increased susceptibility to induced arthritis / MGI
  • abnormal lean body mass / MGI
  • increased circulating insulin-like growth factor I level / MGI
  • abnormal vascular wound healing / MGI
  • sepsis / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • abnormal food intake / MGI
  • increased percent body fat/body weight / MGI
  • increased circulating leptin level / MGI
  • increased body mass index / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased circulating interleukin-6 level / MGI
  • increased circulating interleukin-18 level / MGI
  • decreased circulating interleukin-18 level / MGI
  • increased circulating interleukin-1 beta level / MGI
  • decreased interleukin-6 secretion / MGI
  • decreased transforming growth factor level / MGI
  • increased gonadal fat pad weight / MGI
  • increased abdominal fat pad weight / MGI
  • increased inguinal fat pad weight / MGI
  • increased mesenteric fat pad weight / MGI
  • increased retroperitoneal fat pad weight / MGI
  • enhanced contextual conditioning behavior / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • increased total body fat amount / MGI
  • increased respiratory quotient / MGI
  • immune system phenotype / MGI
  • increased bone resorption / MGI
  • osteomyelitis / MGI
  • dental pulp necrosis / MGI
  • abnormal neutrophil physiology / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • decreased susceptibility to kidney reperfusion injury / MGI
  • decreased susceptibility to experimental autoimmune uveoretinitis / MGI
  • decreased circulating creatinine level / MGI
  • decreased blood urea nitrogen level / MGI
  • delayed tooth eruption / MGI

Literature references

  • Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.;Glaccum M B, Stocking K L, Charrier K, Smith J L, Willis C R, Maliszewski C, Livingston D J, Peschon J J, Morrissey P J, ;1997;Journal of immunology (Baltimore, Md. : 1950);159;3364-71; 9317135

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).