- aortitis / MGI
- immune system phenotype / MGI
- hemorrhage / MGI
- premature death / MGI
- chronic inflammation / MGI
- artery stenosis / MGI
- skin inflammation / MGI
- psoriasis / MGI
- skin lesions / MGI
- abnormal epidermal layer morphology / MGI
- thick epidermis / MGI
- epidermal desquamation / MGI
- abnormal dermal layer morphology / MGI
- thick dermal layer / MGI
- parakeratosis / MGI
- abnormal keratinocyte physiology / MGI
- rheumatoid arthritis / MGI
- pathological neovascularization / MGI
CAnN.129P2(MF1)-Il1rntm1Nick/NickH
Status | Available to order |
EMMA ID | EM:02497 |
International strain name | CAnN.129P2(MF1)-Il1rntm1Nick/NickH |
Alternative name | BALB/cAnNHsd Il1rn |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Il1rntm1Nick, |
Gene/Transgene symbol | Il1rn |
Information from provider
Provider | Martin Nicklin |
Provider affiliation | School of Medicine, University of Sheffield |
Genetic information | Inactivation of all isoforms of Il1rn by targeted replacement. Mutant locus contains plasmid and Neo marker. Strain lacks interleukin-1 receptor antagonist. |
Phenotypic information | Strain sporadically and independently develops rheumatoid-like arthritis, localised psoriasis-like lesions and patchy transmural destructive arteritis of the elastic vessels. Hygiene dependent (negative correlation). Different strain dependence of each disease. This strain, in our SPF lab: 80% affected (each disease independently) at 200 days. |
Breeding history | 129P2/OlaHsd chim. outbred to MF1, inbred 4 gen., barrier rederived, backcrossed to BALB/cAnN. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | homozygous BALB/cAnN |
Breeding at archiving centre | Males were archived by sperm freezing on arrival. No breeding was performed at the archiving centre. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Sterile multifocal osteomyelitis with periostitis and pustulosis / Orphanet_210115
MGI phenotypes (allele matching)
Literature references
- Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene.;Nicklin M J, Hughes D E, Barton J L, Ure J M, Duff G W, ;2000;The Journal of experimental medicine;191;303-12; 10637274
- Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist.;Shepherd Joanna, Little Matthew C, Nicklin Martin J H, ;2004;The Journal of investigative dermatology;122;665-9; 15086551
- Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor.;Shepherd Joanna, Nicklin Martin J H, ;2005;Circulation;111;3135-40; 15939811
- Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.;Abdollahi-Roodsaz Shahla, Joosten Leo A B, Koenders Marije I, Devesa Isabel, Roelofs Mieke F, Radstake Timothy R D J, Heuvelmans-Jacobs Marleen, Akira Shizuo, Nicklin Martin J H, Ribeiro-Dias Fátima, van den Berg Wim B, ;2008;The Journal of clinical investigation;118;205-16; 18060042
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