B6.129P2-Tnfrsf1atm1Blt/Cnrm

Status

Available to order

EMMA IDEM:02523
International strain nameB6.129P2-Tnfrsf1atm1Blt/Cnrm
Alternative nameB6.129S/SvEv-Tnfrsf1a
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTnfrsf1atm1Blt,
Gene/Transgene symbolTnfrsf1a

Information from provider

ProviderHorst Bluethmann
Provider affiliationPharmaceuticals Divisons, F. Hoffmann-La Roche Ltd.
Genetic informationA genomic fragment containing exons II and III and 5' sequences from exon IV of the Tnfrsf1a gene was replaced by a neomycin resistance gene flanked by phosphoglycerate kinase-1 (pgk-1) promoter and poly (A)+ signal sequences. The insertion of the neo cassette resulted in the introduction of new BglII and StuI sites which were used to confirm the targeting event. The Tnfrsf1a homologies provided at both sides of the neo cassette were 868 bp and ~ 5 kb, respectively. The targeting vector was linearized with XbaI before electroporation into E14 embryonic stem cells derived from 129/Sv mice.
Phenotypic informationMice lacking the tumor necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.
Breeding historyBackcrossed for 10 generations to C57BL/6, then intercrossed to generate a homozygous mutant line.
References
  • Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.;Rothe J, Lesslauer W, Lötscher H, Lang Y, Koebel P, Köntgen F, Althage A, Zinkernagel R, Steinmetz M, Bluethmann H, ;1993;Nature;364;798-802; 8395024
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedyes

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
MGI phenotypes (allele matching)
  • abnormal response/metabolism to endogenous compounds / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal sleep pattern / MGI
  • impaired central nervous system regeneration / MGI
  • increased sensitivity to induced cell death / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • impaired humoral immune response / MGI
  • decreased susceptibility to bacterial infection / MGI
  • decreased circulating alanine transaminase level / MGI
  • abnormal Peyer's patch morphology / MGI
  • abnormal immune system physiology / MGI
  • abnormal lymph node B cell domain morphology / MGI
  • abnormal Peyer's patch follicle morphology / MGI
  • increased susceptibility to bacterial infection / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased susceptibility to type I hypersensitivity reaction / MGI
  • decreased Peyer's patch number / MGI
  • absent follicular dendritic cells / MGI
  • decreased IgG1 level / MGI
  • decreased interleukin-6 secretion / MGI

Literature references

  • Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.;Rothe J, Lesslauer W, Lötscher H, Lang Y, Koebel P, Köntgen F, Althage A, Zinkernagel R, Steinmetz M, Bluethmann H, ;1993;Nature;364;798-802; 8395024

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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