MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
129S/SvEv-Gt(ROSA)26Sortm1Coll/H
| Status | Available to order |
| EMMA ID | EM:02530 |
| International strain name | 129S/SvEv-Gt(ROSA)26Sortm1Coll/H |
| Alternative name | GTrosa26 LacZ |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gt(ROSA)26Sortm1Coll, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | William Colledge |
| Provider affiliation | Central Biomedical Services, University of Cambridge |
| Genetic information | A reporter mouse, Gt(ROSA)26Sor-LacZ-tm1Coll, was generated by targeting a mutated LacZ gene to the Gt(ROSA)26Sor locus in mouse embryonic stem (ES) cells. The LacZ gene contains a G to A point mutation, resulting in a Glu to Lys amino-acid substitution at position 461, which abrogates enzymatic activity. The gene is expressed in ES cells, primary embryonic fibroblasts, and in all tissues examined in the adult mouse, including the lung, liver, kidney, spleen, heart, brain and smooth muscle. |
| Phenotypic information | No overt phenotype. |
| Breeding history | Inbred direct from germline chimera on 129S6/SvEv. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- A LacZ-based transgenic mouse for detection of somatic gene repair events in vivo.;Nickerson H D, Colledge W H, ;2004;Gene therapy;11;1351-7; 15229632