129-Ncf1tm1Hbd/H
Status | Available to order |
EMMA ID | EM:00255 |
International strain name | 129-Ncf1tm1Hbd/H |
Alternative name | p47 phox |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Ncf1tm1Hbd, |
Gene/Transgene symbol | Ncf1 |
Information from provider
Provider | Jurgen Roes |
Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
Genetic information | Disruption of the Ncf1 gene by insertion of neo gene in exon 3. |
Phenotypic information | Moderate breeder, impaired innate immunity. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Chronic granulomatous disease / Orphanet_379
MGI phenotypes (allele matching)
Literature references
- Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice.;Harbord Marcus, Novelli Marco, Canas Benito, Power David, Davis Christine, Godovac-Zimmermann Jasminka, Roes Jurgen, Segal Anthony W, ;2002;The Journal of biological chemistry;277;5468-75; 11733538
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