B6.129P2-B2mtm1Unc/Orl

Status

Available to order

EMMA IDEM:00029
International strain nameB6.129P2-B2mtm1Unc/Orl
Alternative namebeta2m°
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolB2mtm1Unc,
Gene/Transgene symbolB2m

Information from provider

ProviderBeverly H. Koller
Provider affiliationc/o CDTA-Orleans
Phenotypic informationThe B2M protein is linked to MHC class I molecules. The mutant mice carry a null mutation in the beta-2 microglobulin (B2m) gene. Obtained by mutation of the B2m gene by homologous recombination (insertion of neomycin-resistance gene). Class I molecules are lacking or unstable on the cell surface, leading to a nearly elimination of the T CD8+ compartment. Cytotoxic immune responses are much altered.
Breeding history129P2/OlaHsd ES cells; 9 generations of backcross to C57BL/6, then intercross.
References
  • Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.;Koller B H, Marrack P, Kappler J W, Smithies O, ;1990;Science (New York, N.Y.);248;1227-30; 2112266

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased level of surface class I molecules / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG level / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased IgM level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased circulating serum albumin level / MGI
  • increased T-helper 1 cell number / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • abnormal T cell number / MGI
  • insulitis / MGI

Literature references

  • Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.;Koller B H, Marrack P, Kappler J W, Smithies O, ;1990;Science (New York, N.Y.);248;1227-30; 2112266

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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