B6.129-B2mtm1Unc H2-Ab1tm1Doi/DoiOrl

Status

Available to order

EMMA IDEM:00030
International strain nameB6.129-B2mtm1Unc H2-Ab1tm1Doi/DoiOrl
Alternative namebeta2m°, Abeta°(MHC)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolB2mtm1Unc,
Gene/Transgene symbolB2m

Information from provider

ProviderDiane MATHIS
Provider affiliationLGME Universite
Phenotypic informationDouble-mutant mice deficient in products of beta-2 microglobulin, and histocompatibility 2, class II antigen A, beta 1 (MHC class I and II) genes. Obtained by crossing of strains carrying the B2m and H2-Ab1 gene mutations. They generally show a deficiency in T lymphocytes (CD4 and CD8 compartments).
Breeding history129P2/OlaHsd and 129S2/SvPas ES cells; 9 generations of backcross to C57BL/6, then intercross.
References
  • Another view of the selective model of thymocyte selection.;Chan S H, Cosgrove D, Waltzinger C, Benoist C, Mathis D, ;1993;Cell;73;225-36; 8097430

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased level of surface class I molecules / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG level / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased IgM level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased circulating serum albumin level / MGI
  • increased T-helper 1 cell number / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • abnormal T cell number / MGI
  • insulitis / MGI
  • abnormal neuron proliferation / MGI
  • abnormal immune system morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal immune system cell morphology / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • reduced fertility / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal B cell physiology / MGI
  • abnormal immune system organ morphology / MGI
  • abnormal cytokine secretion / MGI
  • decreased susceptibility to parasitic infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • abnormal lymph node cell ratio / MGI

Literature references

  • Another view of the selective model of thymocyte selection.;Chan S H, Cosgrove D, Waltzinger C, Benoist C, Mathis D, ;1993;Cell;73;225-36; 8097430

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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