- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- anemia / MGI
- skin edema / MGI
- interstitial pneumonia / MGI
- neoplasm / MGI
- premature death / MGI
- abnormal T cell differentiation / MGI
- abnormal lymph node morphology / MGI
- increased immunoglobulin level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- increased autoantibody level / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased lymphocyte cell number / MGI
- increased T cell number / MGI
- decreased B cell number / MGI
- decreased cytotoxic T cell cytolysis / MGI
- renal/urinary system phenotype / MGI
- cardiovascular system phenotype / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- mortality/aging / MGI
- decreased granulocyte number / MGI
- abnormal hepatocyte morphology / MGI
- demyelination / MGI
- abnormal osteoclast physiology / MGI
- focal hepatic necrosis / MGI
- brain inflammation / MGI
- eye inflammation / MGI
- liver inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal sperm number / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal sperm physiology / MGI
- abnormal eye electrophysiology / MGI
- CNS inflammation / MGI
- decreased hepatocyte apoptosis / MGI
- abnormal NK cell physiology / MGI
- abnormal T cell physiology / MGI
- decreased neuron apoptosis / MGI
- abnormal T cell proliferation / MGI
- abnormal T cell morphology / MGI
- abnormal interleukin level / MGI
- impaired macrophage phagocytosis / MGI
- increased spleen weight / MGI
- homeostasis/metabolism phenotype / MGI
- increased apoptosis / MGI
- dermatitis / MGI
- increased IgE level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- decreased susceptibility to injury / MGI
- immune system phenotype / MGI
- increased circulating tumor necrosis factor level / MGI
- increased histiocytic sarcoma incidence / MGI
- reproductive system phenotype / MGI
B6;C3-Faslgld/Orl
Status | Available to order |
EMMA ID | EM:00036 |
International strain name | B6;C3-Faslgld/Orl |
Alternative name | C57BL/6 - gld |
Strain type | Spontaneous |
Allele/Transgene symbol | Faslgld, |
Gene/Transgene symbol | Fasl |
Information from provider
Provider | S Nagata |
Provider affiliation | Osaka Bioscience Institute |
Phenotypic information | Mutant strain for Fasl-gld (Fas ligand, generalized lymphoproliferative disease) allele; prev. nomenclature: Tnfsf6-gld (tumor necrosis factor ligand superfamily member 6, gld). The gld allele is generated by a point mutation in the C-terminal region of the Fasl protein. The homozygous gld mice develop lymphadenopathy and have autoimmune diseases. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (allele matching)
Literature references
- Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.;Takahashi T, Tanaka M, Brannan C I, Jenkins N A, Copeland N G, Suda T, Nagata S, ;1994;Cell;76;969-76; 7511063
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