C3H;C-Tuba1aJna/H

Status

Available to order

EMMA IDEM:00377
International strain nameC3H;C-Tuba1aJna/H
Alternative nameGENA227
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolTuba1aJna,
Gene/Transgene symbolTuba1a

Information from provider

ProviderPat Nolan
Provider affiliationMRC Mammalian Genetics Unit
Phenotypic informationMice heterozygous for this mutation have high locomotor activity which can be confirmed by monitoring locomotor activity for 35 minutes. Homozygotes have not been bred.
References
  • Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.;Keays David A, Tian Guoling, Poirier Karine, Huang Guo-Jen, Siebold Christian, Cleak James, Oliver Peter L, Fray Martin, Harvey Robert J, Molnár Zoltán, Piñon Maria C, Dear Neil, Valdar William, Brown Steve D M, Davies Kay E, Rawlins J Nicholas P, Cowan Nicholas J, Nolan Patrick, Chelly Jamel, Flint Jonathan, ;2007;Cell;128;45-57; 17218254

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal cerebral cortex morphology / MGI
  • abnormal visual cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal dentate gyrus morphology / MGI
  • abnormal Ammon gyrus morphology / MGI
  • abnormal somatosensory cortex morphology / MGI
  • decreased body weight / MGI
  • decreased anxiety-related response / MGI
  • hyperactivity / MGI
  • abnormal nest building behavior / MGI
  • abnormal hippocampal mossy fiber morphology / MGI
  • abnormal auditory cortex morphology / MGI
  • abnormal neuronal migration / MGI
  • abnormal hippocampus pyramidal cell layer / MGI
  • abnormal spatial working memory / MGI
  • decreased hippocampus pyramidal cell number / MGI

Literature references

  • Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.;Keays David A, Tian Guoling, Poirier Karine, Huang Guo-Jen, Siebold Christian, Cleak James, Oliver Peter L, Fray Martin, Harvey Robert J, Molnár Zoltán, Piñon Maria C, Dear Neil, Valdar William, Brown Steve D M, Davies Kay E, Rawlins J Nicholas P, Cowan Nicholas J, Nolan Patrick, Chelly Jamel, Flint Jonathan, ;2007;Cell;128;45-57; 17218254

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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