- small thymus / MGI
- abnormal thymus morphology / MGI
- increased incidence of corneal inflammation / MGI
- increased susceptibility to viral infection / MGI
- blepharitis / MGI
- corneal vascularization / MGI
- abnormal nail morphology / MGI
- nail dystrophy / MGI
- abnormal nail plate morphology / MGI
- abnormal nail matrix morphology / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased leukocyte cell number / MGI
- abnormal liver morphology / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- athymia / MGI
- small ovary / MGI
- thin skin / MGI
- decreased body weight / MGI
- decreased body size / MGI
- wavy vibrissae / MGI
- short vibrissae / MGI
- absent vibrissae / MGI
- postnatal growth retardation / MGI
- reduced male fertility / MGI
- female infertility / MGI
- abnormal estrous cycle / MGI
- premature death / MGI
- abnormal lymph node T cell domain morphology / MGI
- abnormal Peyer's patch germinal center morphology / MGI
- asthenozoospermia / MGI
- hairless / MGI
- abnormal venule morphology / MGI
- abnormal splenic cell ratio / MGI
- coiled sperm flagellum / MGI
- postnatal lethality, incomplete penetrance / MGI
- impaired spatial learning / MGI
- increased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- abnormal compact bone morphology / MGI
- abnormal coat/ hair morphology / MGI
- abnormal hair follicle morphology / MGI
- deformed nails / MGI
- abnormal thymus development / MGI
- abnormal epidermal layer morphology / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cuticle / MGI
- abnormal hair cortex morphology / MGI
- endocrine/exocrine gland phenotype / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- reduced hair shaft melanin granule number / MGI
- abnormal hair cortex keratinization / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- short nails / MGI
- decreased susceptibility to bacterial infection / MGI
- decreased circulating alanine transaminase level / MGI
- ascites / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-2 level / MGI
- chromosomal instability / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal circulating cytokine level / MGI
- increased plasmacytoma incidence / MGI
- decreased circulating luteinizing hormone level / MGI
- decreased circulating follicle stimulating hormone level / MGI
- abnormal circulating gonadotropin level / MGI
- abnormal T cell activation / MGI
- abnormal lymph node morphology / MGI
- increased length of allograft survival / MGI
- decreased lymphocyte cell number / MGI
- decreased T cell number / MGI
- abnormal spleen physiology / MGI
- abnormal muscle morphology / MGI
- decreased skeletal muscle mass / MGI
- decreased skeletal muscle fiber size / MGI
STOCK Foxn1nu/Orl
Status | Available to order |
EMMA ID | EM:00038 |
International strain name | STOCK Foxn1nu/Orl |
Alternative name | C57BL/6 - nu |
Strain type | Spontaneous |
Allele/Transgene symbol | Foxn1nu, |
Gene/Transgene symbol | Foxn1 |
Information from provider
Provider | CDTA unknown |
Provider affiliation | CNRS-Orleans |
Phenotypic information | Mutant strain with Foxn1 (forkhead box N1) nu allele (prev. nomenclature: nu, nude mutation). The nude mutation is a single, autosomal recessive mutation. The Foxn1nu locus is localized on chromosome 11. Congenic nude strains show the pleiotropic phenotype of hairlessness, athymia and T-cell deficiency. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous , heterozygous C57BL/6J |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to FOXN1 deficiency / Orphanet_169095
MGI phenotypes (allele matching)
Literature references
- Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis.;Hirasawa T, Yamashita H, Makino S, ;1998;Experimental animals;47;63-7; 9498115
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