STOCK Foxn1nu/Orl

Status

Available to order

EMMA IDEM:00038
International strain nameSTOCK Foxn1nu/Orl
Alternative nameC57BL/6 - nu
Strain typeSpontaneous
Allele/Transgene symbolFoxn1nu,
Gene/Transgene symbolFoxn1

Information from provider

ProviderCDTA unknown
Provider affiliationCNRS-Orleans
Phenotypic informationMutant strain with Foxn1 (forkhead box N1) nu allele (prev. nomenclature: nu, nude mutation). The nude mutation is a single, autosomal recessive mutation. The Foxn1nu locus is localized on chromosome 11. Congenic nude strains show the pleiotropic phenotype of hairlessness, athymia and T-cell deficiency.
References
  • Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis.;Hirasawa T, Yamashita H, Makino S, ;1998;Experimental animals;47;63-7; 9498115

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous , heterozygous C57BL/6J

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • small thymus / MGI
  • abnormal thymus morphology / MGI
  • increased incidence of corneal inflammation / MGI
  • increased susceptibility to viral infection / MGI
  • blepharitis / MGI
  • corneal vascularization / MGI
  • abnormal nail morphology / MGI
  • nail dystrophy / MGI
  • abnormal nail plate morphology / MGI
  • abnormal nail matrix morphology / MGI
  • decreased susceptibility to parasitic infection / MGI
  • decreased leukocyte cell number / MGI
  • abnormal liver morphology / MGI
  • abnormal spleen morphology / MGI
  • small spleen / MGI
  • athymia / MGI
  • small ovary / MGI
  • thin skin / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • wavy vibrissae / MGI
  • short vibrissae / MGI
  • absent vibrissae / MGI
  • postnatal growth retardation / MGI
  • reduced male fertility / MGI
  • female infertility / MGI
  • abnormal estrous cycle / MGI
  • premature death / MGI
  • abnormal lymph node T cell domain morphology / MGI
  • abnormal Peyer's patch germinal center morphology / MGI
  • asthenozoospermia / MGI
  • hairless / MGI
  • abnormal venule morphology / MGI
  • abnormal splenic cell ratio / MGI
  • coiled sperm flagellum / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • impaired spatial learning / MGI
  • increased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal compact bone morphology / MGI
  • abnormal coat/ hair morphology / MGI
  • abnormal hair follicle morphology / MGI
  • deformed nails / MGI
  • abnormal thymus development / MGI
  • abnormal epidermal layer morphology / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • abnormal epidermis stratum granulosum morphology / MGI
  • abnormal epidermis stratum corneum morphology / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal hair cuticle / MGI
  • abnormal hair cortex morphology / MGI
  • endocrine/exocrine gland phenotype / MGI
  • abnormal cutaneous collagen fibril morphology / MGI
  • reduced hair shaft melanin granule number / MGI
  • abnormal hair cortex keratinization / MGI
  • abnormal hair follicle inner root sheath morphology / MGI
  • short nails / MGI
  • decreased susceptibility to bacterial infection / MGI
  • decreased circulating alanine transaminase level / MGI
  • ascites / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased circulating interleukin-2 level / MGI
  • chromosomal instability / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • abnormal circulating cytokine level / MGI
  • increased plasmacytoma incidence / MGI
  • decreased circulating luteinizing hormone level / MGI
  • decreased circulating follicle stimulating hormone level / MGI
  • abnormal circulating gonadotropin level / MGI
  • abnormal T cell activation / MGI
  • abnormal lymph node morphology / MGI
  • increased length of allograft survival / MGI
  • decreased lymphocyte cell number / MGI
  • decreased T cell number / MGI
  • abnormal spleen physiology / MGI
  • abnormal muscle morphology / MGI
  • decreased skeletal muscle mass / MGI
  • decreased skeletal muscle fiber size / MGI

Literature references

  • Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis.;Hirasawa T, Yamashita H, Makino S, ;1998;Experimental animals;47;63-7; 9498115

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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