- abnormal skeletal muscle fiber morphology / MGI
- dystrophic muscle / MGI
- abnormal circulating pyruvate kinase level / MGI
- muscle degeneration / MGI
- myopathy / MGI
- reduced female fertility / MGI
- abnormal muscle physiology / MGI
- abnormal muscle morphology / MGI
- muscular atrophy / MGI
- skeletal muscle necrosis / MGI
- dilated sarcoplasmic reticulum / MGI
- increased variability of skeletal muscle fiber size / MGI
- skeletal muscle fibrosis / MGI
- increased circulating creatine kinase level / MGI
- decreased aerobic running capacity / MGI
- increased skeletal muscle mass / MGI
- increased growth hormone level / MGI
- muscle phenotype / MGI
- adipose tissue phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- myocardial necrosis / MGI
- abnormal corticotroph morphology / MGI
- increased somatotroph cell size / MGI
- centrally nucleated skeletal muscle fibers / MGI
- increased skeletal muscle fiber number / MGI
- skeletal muscle fiber necrosis / MGI
- increased quadriceps weight / MGI
- increased skeletal muscle weight / MGI
- enlarged heart / MGI
- increased body size / MGI
- impaired coordination / MGI
- abnormal grip strength / MGI
- impaired skeletal muscle contractility / MGI
- calcified muscle / MGI
- decreased cardiac output / MGI
- myositis / MGI
- increased susceptibility to noise-induced hearing loss / MGI
- decreased cardiac muscle contractility / MGI
- cardiomyopathy / MGI
- cardiovascular system phenotype / MGI
- increased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- increased interleukin-12 secretion / MGI
- increased interleukin-2 secretion / MGI
- increased interleukin-4 secretion / MGI
- increased interleukin-6 secretion / MGI
- increased skeletal muscle fiber diameter / MGI
- skeletal muscle degeneration / MGI
- skeletal muscle hypertrophy / MGI
- decreased grip strength / MGI
- decreased cardiac stroke volume / MGI
- abnormal auditory brainstem response waveform shape / MGI
- increased or absent threshold for auditory brainstem response / MGI
- abnormal skeletal muscle regeneration / MGI
- increased creatine kinase activity / MGI
- decreased body size / MGI
- heart inflammation / MGI
- dystrophic cardiac calcinosis / MGI
- decreased skeletal muscle mass / MGI
- decreased skeletal muscle fiber size / MGI
- decreased skeletal muscle fiber diameter / MGI
- skeletal muscle fiber atrophy / MGI
- cardiac muscle degeneration / MGI
- skeletal muscle atrophy / MGI
- abnormal skeletal muscle morphology / MGI
- abnormal neuromuscular synapse morphology / MGI
- abnormal diaphragm morphology / MGI
- abnormal intercostal muscle morphology / MGI
- nervous system phenotype / MGI
- abnormal muscle tone / MGI
- abnormal muscle electrophysiology / MGI
- abnormal muscle contractility / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- abnormal skeletal muscle satellite cell proliferation / MGI
- skeletal muscle endomysial fibrosis / MGI
- anterior subcapsular cataracts / MGI
- nuclear cataracts / MGI
- abnormal scalene muscle morphology / MGI
- abnormal vertebral column morphology / MGI
- increased transforming growth factor level / MGI
- skeletal muscle fiber degeneration / MGI
- impaired exercise endurance / MGI
- muscle weakness / MGI
- decreased body weight / MGI
- decreased skeletal muscle fiber number / MGI
- increased total body fat amount / MGI
- decreased quadriceps weight / MGI
- decreased skeletal muscle weight / MGI
STOCK Dmdmdx Tg(Ckm-Dmd_iDp71)MCA-1Chmb/H
Status | Available to order |
EMMA ID | EM:00391 |
International strain name | STOCK Dmdmdx Tg(Ckm-Dmd_iDp71)MCA-1Chmb/H |
Alternative name | MCA |
Strain type | Spontaneous |
Allele/Transgene symbol | Dmdmdx, |
Gene/Transgene symbol | Dmd |
Information from provider
Provider | Kay Davies |
Provider affiliation | University of Oxford |
Genetic information | MCA/mdx mice are transgenic for the Dp71 transgene (expressing the Dp71 dystrophin mRNA isoform), which is inducible by the withdrawal or administration of tetracycline in the drinking water when crossed to the MCK-tTA mouse line. |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial isolated dilated cardiomyopathy / Orphanet_154
- Duchenne muscular dystrophy / Orphanet_98896
- Becker muscular dystrophy / Orphanet_98895
- X-linked non-syndromic intellectual disability / Orphanet_777
- Symptomatic form of muscular dystrophy of Duchenne and Becker in female carriers / Orphanet_206546
MGI phenotypes (allele matching)
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