C57BL/6NTac-Cpeb4tm1a(EUCOMM)Wtsi/Cnrm

Status

Available to order

EMMA IDEM:04002
International strain nameC57BL/6NTac-Cpeb4tm1a(EUCOMM)Wtsi/Cnrm
Alternative nameEPD0060_4_E10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCpeb4tm1a(EUCOMM)Wtsi,
Gene/Transgene symbolCpeb4
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0060_4_E10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development.;Sibilio Annarita, Suñer Clara, Fernández-Alfara Marcos, Martín Judit, Berenguer Antonio, Calon Alexandre, Chanes Veronica, Millanes-Romero Alba, Fernández-Miranda Gonzalo, Batlle Eduard, Fernández Mercedes, Méndez Raúl, ;2022;iScience;25;103790; 35243213

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal bone structure / IMPC
MGI phenotypes (allele matching)
  • abnormal erythropoiesis / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • impaired coordination / MGI
  • abnormal suckling behavior / MGI
  • respiratory distress / MGI
  • nervous system phenotype / MGI
  • abnormal axon extension / MGI
  • muscle phenotype / MGI
  • abnormal cell physiology / MGI
  • abnormal neurite morphology / MGI
  • decreased survivor rate / MGI
  • absent gastric milk in neonates / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • lethality during fetal growth through weaning, incomplete penetrance / MGI
  • abnormal fetal derived definitive erythrocyte morphology / MGI
  • decreased fetal derived definitive erythrocyte cell number / MGI
  • abnormal phrenic nerve innervation pattern to diaphragm / MGI

Literature references

  • Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development.;Sibilio Annarita, Suñer Clara, Fernández-Alfara Marcos, Martín Judit, Berenguer Antonio, Calon Alexandre, Chanes Veronica, Millanes-Romero Alba, Fernández-Miranda Gonzalo, Batlle Eduard, Fernández Mercedes, Méndez Raúl, ;2022;iScience;25;103790; 35243213
  • Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration.;Shin Jihae, Salameh Johnny S, Richter Joel D, ;2016;Scientific reports;6;29395; 27381259

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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