B6.Cg-Jmjd6tm1.1Gbf/Ieg

Status

Available to order

EMMA IDEM:04329
International strain nameB6.Cg-Jmjd6tm1.1Gbf/Ieg
Alternative nameC57Bl/6J-Jmjd6 tm1.1 Gbf
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolJmjd6tm1.1Gbf,
Gene/Transgene symbolJmjd6

Information from provider

ProviderAndreas Lengeling
Provider affiliationTierhaus TEE, Helmholtz Centre for Infection Research
Genetic informationIntragenic deletion of exon 1 and 2. This allele was created by removing the floxed neomycin cassette from Jmjd6tm1Gbf mice by crossing them to a CMV cre deleter line.
Phenotypic informationMice homozygous for disruption in this gene show neonatal lethality. Abnormalities are observed in the nervous, cardiovascular, digestive, renal, hematopoietic, and immune systems.
Breeding historyThe mutation was generated in Bruce 4 ES cells. Germline chimeras were bred to C57BL/6J mice to establish a breeding colony. Since then the strain has been maintained by brother x sister matings (>15 generations).
References
  • The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal.;Böse Jens, Gruber Achim D, Helming Laura, Schiebe Stefanie, Wegener Ivonne, Hafner Martin, Beales Marianne, Köntgen Frank, Lengeling Andreas, ;2004;Journal of biology;3;15; 15345036
  • Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique.;Schneider Jürgen E, Böse Jens, Bamforth Simon D, Gruber Achim D, Broadbent Carol, Clarke Kieran, Neubauer Stefan, Lengeling Andreas, Bhattacharya Shoumo, ;2004;BMC developmental biology;4;16; 15615595
  • Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.;Hahn Phillip, Böse Jens, Edler Stefanie, Lengeling Andreas, ;2008;BMC genomics;9;293; 18564434
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6J, wild-type C57BL/6J
Stage of embryos2-cell

Disease and phenotype information

MGI phenotypes (allele matching)
  • ventricular septal defect / MGI

Literature references

  • The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal.;Böse Jens, Gruber Achim D, Helming Laura, Schiebe Stefanie, Wegener Ivonne, Hafner Martin, Beales Marianne, Köntgen Frank, Lengeling Andreas, ;2004;Journal of biology;3;15; 15345036
  • Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique.;Schneider Jürgen E, Böse Jens, Bamforth Simon D, Gruber Achim D, Broadbent Carol, Clarke Kieran, Neubauer Stefan, Lengeling Andreas, Bhattacharya Shoumo, ;2004;BMC developmental biology;4;16; 15615595
  • Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.;Hahn Phillip, Böse Jens, Edler Stefanie, Lengeling Andreas, ;2008;BMC genomics;9;293; 18564434

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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