- ventricular septal defect / MGI
B6.Cg-Jmjd6tm1.1Gbf/Ieg
Status | Available to order |
EMMA ID | EM:04329 |
International strain name | B6.Cg-Jmjd6tm1.1Gbf/Ieg |
Alternative name | C57Bl/6J-Jmjd6 tm1.1 Gbf |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Jmjd6tm1.1Gbf, |
Gene/Transgene symbol | Jmjd6 |
Information from provider
Provider | Andreas Lengeling |
Provider affiliation | Tierhaus TEE, Helmholtz Centre for Infection Research |
Genetic information | Intragenic deletion of exon 1 and 2. This allele was created by removing the floxed neomycin cassette from Jmjd6tm1Gbf mice by crossing them to a CMV cre deleter line. |
Phenotypic information | Mice homozygous for disruption in this gene show neonatal lethality. Abnormalities are observed in the nervous, cardiovascular, digestive, renal, hematopoietic, and immune systems. |
Breeding history | The mutation was generated in Bruce 4 ES cells. Germline chimeras were bred to C57BL/6J mice to establish a breeding colony. Since then the strain has been maintained by brother x sister matings (>15 generations). |
References |
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Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal.;Böse Jens, Gruber Achim D, Helming Laura, Schiebe Stefanie, Wegener Ivonne, Hafner Martin, Beales Marianne, Köntgen Frank, Lengeling Andreas, ;2004;Journal of biology;3;15; 15345036
- Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique.;Schneider Jürgen E, Böse Jens, Bamforth Simon D, Gruber Achim D, Broadbent Carol, Clarke Kieran, Neubauer Stefan, Lengeling Andreas, Bhattacharya Shoumo, ;2004;BMC developmental biology;4;16; 15615595
- Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.;Hahn Phillip, Böse Jens, Edler Stefanie, Lengeling Andreas, ;2008;BMC genomics;9;293; 18564434
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