FVB-Tg(tetO-Hgf,-EGFP)24Tcre/Cnrm

Status	Available to order
EMMA ID	EM:04364
International strain name	FVB-Tg(tetO-Hgf,-EGFP)24Tcre/Cnrm
Alternative name	Hgf-TetO-GFP
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(tetO-Hgf, -EGFP)24Tcre
Gene/Transgene symbol	Tg(tetO-Hgf,-EGFP)24Tcre

Information from provider

Provider	Tiziana Crepaldi
Provider affiliation	Anatomy Pharmacology and Forensic Medicine, University of Turin
Genetic information	In order to obtain tetracycline controlled expression of Hgf, the murine Hgf cDNA was cloned into the pBI-eGFP vector (Clontech) to generate the bidirectional Hgf-TetO-GFP responder. Gene expression was induced in the heart by crossing the Hgf-TetO-GFP transgenic line with mice which carry a transgene consisting of the tTA driven by cardiac alpha-MHC promoter. The GFP gene facilitates detection of responder transgene on whole organ as well as in tissue sections.
Phenotypic information	No phenotype was observed in single transgenic mice.
References	A mouse model for spatial and temporal expression of HGF in the heart.;Riess Ilan, Sala Valentina, Leo Christian, Demaria Marco, Gatti Stefano, Gallo Simona, Fitou Amandine, Boero Ombretta, Levi Renzo, Cuccovillo Ivan, Molla Fabiola, De Angelis Noeleen, Staszewsky Lidia, Latini Roberto, Crepaldi Tiziana, ;2011;Transgenic research;20;1203-16; 21360304 Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes.;Morena Deborah, Maestro Nicola, Bersani Francesca, Forni Paolo Emanuele, Lingua Marcello Francesco, Foglizzo Valentina, Šćepanović Petar, Miretti Silvia, Morotti Alessandro, Shern Jack F, Khan Javed, Ala Ugo, Provero Paolo, Sala Valentina, Crepaldi Tiziana, Gasparini Patrizia, Casanova Michela, Ferrari Andrea, Sozzi Gabriella, Chiarle Roberto, Ponzetto Carola, Taulli Riccardo, ;2016;eLife;5;; 26987019
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

A mouse model for spatial and temporal expression of HGF in the heart.;Riess Ilan, Sala Valentina, Leo Christian, Demaria Marco, Gatti Stefano, Gallo Simona, Fitou Amandine, Boero Ombretta, Levi Renzo, Cuccovillo Ivan, Molla Fabiola, De Angelis Noeleen, Staszewsky Lidia, Latini Roberto, Crepaldi Tiziana, ;2011;Transgenic research;20;1203-16; 21360304
Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes.;Morena Deborah, Maestro Nicola, Bersani Francesca, Forni Paolo Emanuele, Lingua Marcello Francesco, Foglizzo Valentina, Šćepanović Petar, Miretti Silvia, Morotti Alessandro, Shern Jack F, Khan Javed, Ala Ugo, Provero Paolo, Sala Valentina, Crepaldi Tiziana, Gasparini Patrizia, Casanova Michela, Ferrari Andrea, Sozzi Gabriella, Chiarle Roberto, Ponzetto Carola, Taulli Riccardo, ;2016;eLife;5;; 26987019

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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