MGI phenotypes (allele matching)
B6.129P2(FVB)-Fgf3tm1Sng/Cnbc
| Status | Available to order |
| EMMA ID | EM:04387 |
| International strain name | B6.129P2(FVB)-Fgf3tm1Sng/Cnbc |
| Alternative name | Fgf3ko |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Fgf3tm1Sng, |
| Gene/Transgene symbol | Fgf3 |
Information from provider
| Provider | Thomas Schimmang |
| Provider affiliation | IBGM |
| Genetic information | Targeting construct from 129. The coding region of Fgf3 is deleted. |
| Phenotypic information | Homozygous mutants are viable and fertile. Tail defect with 100% penetrance. Inner ear defect with variable penetrance and expressivity. |
| Breeding history | Backcrossed on C57BL/6 for 10 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Deafness with labyrinthine aplasia, microtia, and microdontia / Orphanet_90024
Literature references
- Requirements for FGF3 and FGF10 during inner ear formation.;Alvarez Yolanda, Alonso Maria Teresa, Vendrell Victor, Zelarayan Laura Cecilia, Chamero Pablo, Theil Thomas, Bösl Michael R, Kato Shigeaki, Maconochie Mark, Riethmacher Dieter, Schimmang Thomas, ;2003;Development (Cambridge, England);130;6329-38; 14623822