MGI phenotypes (allele matching)
- decreased rhombomere 3 size / MGI
STOCK Egr2tm3Pch Tg(CD2-icre)4Kio/H
| Status | Available to order |
| EMMA ID | EM:04482 |
| International strain name | STOCK Egr2tm3Pch Tg(CD2-icre)4Kio/H |
| Alternative name | Egr-2-cKO |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CD2-icre)4Kio, |
| Gene/Transgene symbol | Tg(CD2-icre)4Kio |
Information from provider
| Provider | Ping Wang |
| Provider affiliation | Institute of Cell and Molecular Science, Bart and London School of Medicien and Dentistry |
| Genetic information | Egr2 loxP and CD2-cre. |
| Phenotypic information | Spontaneous autoimmune diseases start at late age (12 months). |
| Breeding history | Inbred |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6 x CBA |
| Breeding at archiving centre | Males were archived upon arrival. No breeding was performed at the archiving centre. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Dejerine-Sottas syndrome / Orphanet_64748
- Charcot-Marie-Tooth disease type 1D / Orphanet_101084
- Charcot-Marie-Tooth disease type 4E / Orphanet_99951
Literature references
- Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease.;Zhu Bo, Symonds Alistair L J, Martin Joanne E, Kioussis Dimitris, Wraith David C, Li Suling, Wang Ping, ;2008;The Journal of experimental medicine;205;2295-307; 18779345