B6.129-Scn10atm2(cre)Jwo/H
| Status | Available to order |
| EMMA ID | EM:04582 |
| International strain name | B6.129-Scn10atm2(cre)Jwo/H |
| Alternative name | Nav1.8Cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Scn10atm2(cre)Jwo, |
| Gene/Transgene symbol | Scn10a |
Information from provider
| Provider | Mohammed Nassar |
| Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
| Genetic information | cre recombinase is expressed from the Scn10a (Nav1.8) locus; expression of cre is restricted to sensory neurons. |
| Phenotypic information | No phenotype in the heterozygotes. Some pain deficits in homozygotes. |
| Breeding history | Backcrossed to C57BL/6 from 129, inbred crossed for a few generations and then outcrossed to C57BL/6 every few generations. Currently inbred to keep homozygosity. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Breeding at archiving centre | Males were archived upon arrival at the archiving centre. No breeding was performed |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Romano-Ward syndrome / Orphanet_101016
- Sodium channelopathy-related small fiber neuropathy / Orphanet_306577
Literature references
- Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice.;Stirling L Caroline, Forlani Greta, Baker Mark D, Wood John N, Matthews Elizabeth A, Dickenson Anthony H, Nassar Mohammed A, ;2005;Pain;113;27-36; 15621361
- Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling.;Megat Salim, Ray Pradipta R, Tavares-Ferreira Diana, Moy Jamie K, Sankaranarayanan Ishwarya, Wanghzou Andi, Fang Lou Tzu, Barragan-Iglesias Paulino, Campbell Zachary T, Dussor Gregory, Price Theodore J, ;2019;The Journal of neuroscience : the official journal of the Society for Neuroscience;39;6829-6847; 31253755
- Ablation of sensory nerves favours melanoma progression.;Prazeres Pedro H D M, Leonel Caroline, Silva Walison N, Rocha Beatriz G S, Santos Gabryella S P, Costa Alinne C, Picoli Caroline C, Sena Isadora F G, Gonçalves William A, Vieira Mariana S, Costa Pedro A C, Campos Leda M C C, Lopes Miriam T P, Costa Marcos R, Resende Rodrigo R, Cunha Thiago M, Mintz Akiva, Birbrair Alexander, ;2020;Journal of cellular and molecular medicine;24;9574-9589; 32691511
- Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression.;Costa Pedro A C, Silva Walison N, Prazeres Pedro H D M, Picoli Caroline C, Guardia Gabriela D A, Costa Alinne C, Oliveira Mariana A, Guimarães Pedro P G, Gonçalves Ricardo, Pinto Mauro C X, Amorim Jaime H, Azevedo Vasco A C, Resende Rodrigo R, Russo Remo C, Cunha Thiago M, Galante Pedro A F, Mintz Akiva, Birbrair Alexander, ;2021;Acta neuropathologica communications;9;183; 34784974