MGI phenotypes (allele matching)
B6;129S2-Nr4a1tm1Jmi/Cnbc
| Status | Available to order |
| EMMA ID | EM:04655 |
| International strain name | B6;129S2-Nr4a1tm1Jmi/Cnbc |
| Alternative name | Nr4a1(tm1Jmi) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nr4a1tm1Jmi, |
| Gene/Transgene symbol | Nr4a1 |
Information from provider
| Provider | Jeffrey Milbrandt |
| Provider affiliation | Washington University School of Medicine |
| Genetic information | Disruption caused by insertion of vector. Exon 2 was disrupted by the insertion of a neomycin resistance gene. Northern blot analysis of total thymic RNA showed an absence of transcript in homozygous mutant mice. |
| Phenotypic information | Homozygous null mice are viable and fertile. They show insulin resistance and altered systemic glucose metabolism. |
| Breeding history | Mice were maintained in a C57BL/6 x 129 mixed background, randomly bred. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 8-cell |
Disease and phenotype information
Literature references
- Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77).;Lee S L, Wesselschmidt R L, Linette G P, Kanagawa O, Russell J H, Milbrandt J, ;1995;Science (New York, N.Y.);269;532-5; 7624775
- Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice.;Crawford P A, Sadovsky Y, Woodson K, Lee S L, Milbrandt J, ;1995;Molecular and cellular biology;15;4331-16; 7623827
- Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes.;Zheng D, Butler L S, McNamara J O, ;1998;Neuroscience;83;251-8; 9466414
- Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.;Mullican Shannon E, Zhang Shuo, Konopleva Marina, Ruvolo Vivian, Andreeff Michael, Milbrandt Jeffrey, Conneely Orla M, ;2007;Nature medicine;13;730-5; 17515897
- Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.;Chao Lily C, Wroblewski Kevin, Zhang Zidong, Pei Liming, Vergnes Laurent, Ilkayeva Olga R, Ding Shi Ying, Reue Karen, Watt Matthew J, Newgard Christopher B, Pilch Paul F, Hevener Andrea L, Tontonoz Peter, ;2009;Diabetes;58;2788-96; 19741162