B6Brd;B6N-Tyrc-Brd Mcph1tm1a(EUCOMM)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:04808
International strain nameB6Brd;B6N-Tyrc-Brd Mcph1tm1a(EUCOMM)Wtsi/WtsiCnbc
Alternative nameEPD0080_2_A02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolMcph1tm1a(EUCOMM)Wtsi,
Gene/Transgene symbolMcph1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0080_2_A02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • decreased body weight / IMPC
  • abnormal cornea morphology / IMPC
  • corneal opacity / IMPC
  • male infertility / IMPC
  • female infertility / IMPC
  • decreased lean body mass / IMPC
  • abnormal behavior / IMPC
  • absent pinna reflex / IMPC
MGI phenotypes (allele matching)
  • microcephaly / MGI
  • small gonad / MGI
  • microphthalmia / MGI
  • abnormal lens morphology / MGI
  • cataract / MGI
  • abnormal cornea morphology / MGI
  • corneal opacity / MGI
  • disorganized retinal layers / MGI
  • abnormal reproductive system morphology / MGI
  • abnormal fertility/fecundity / MGI
  • abnormal auditory brainstem response / MGI
  • increased B cell number / MGI
  • abnormal eye anterior chamber morphology / MGI
  • abnormal corneal stroma morphology / MGI
  • corneal vascularization / MGI
  • absent pinna reflex / MGI
  • chromosomal instability / MGI
  • decreased bone mineral content / MGI
  • decreased bone trabecula number / MGI
  • decreased trabecular bone mass / MGI
  • decreased trabecular bone volume / MGI
  • increased cornea thickness / MGI
  • persistent hyaloid artery / MGI
  • decreased bone mineral density / MGI
  • decreased body weight / MGI
  • abnormal eye pigmentation / MGI
  • increased thermal nociceptive threshold / MGI
  • decreased lean body mass / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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