129P2/OlaHsd-Wt1tm1Mlh/H

Status

Available to order

EMMA IDEM:04835
International strain name129P2/OlaHsd-Wt1tm1Mlh/H
Alternative nameWt1(tmT396)
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolWt1tm1Mlh,
Gene/Transgene symbolWt1

Information from provider

ProviderColin Miles
Provider affiliationInstitute of Human Genetics, Newcastle University
Genetic informationTargeted mutation truncating Wilms' tumour gene (Wt1) within exon 9. Similar to mutations associated with Denys-Drash syndrome.
Phenotypic informationHeterozygous mutant mice develop glomerulosclerosis (typical of Denys-Drash syndrome) with age.
Breeding historyPure 129/Ola background strain produced from directly backcrossing chimaeric males with 129/Ola females. Heterozygous females are not fertile, so line is maintained through heterozygous males.
References
  • Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).;Patek Charles E, Brownstein David G, Fleming Stewart, Wroe Caroline, Rose Lorraine, Webb Anna, Berry Rachel L, Devenney Paul S, Walker Marion, Maddocks Oliver D K, Lawrence Nicola J, Harrison David J, Wood Katrina M, Miles Colin G, Hooper Martin L, ;2008;Transgenic research;17;459-75; 18040647
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous 129P2/OlaHsd
Breeding at archiving centreMales were archived upon arrival. No breeding was performed at the archiving centre.

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • kidney cortex cysts / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • glomerulosclerosis / MGI
  • abnormal mesangial cell morphology / MGI
  • juxtaglomerular cell hyperplasia / MGI
  • expanded mesangial matrix / MGI
  • renal cast / MGI
  • mesangial cell hyperplasia / MGI
  • podocyte hypertrophy / MGI
  • abnormal heart development / MGI
  • abnormal heart shape / MGI
  • abnormal kidney development / MGI
  • abnormal liver development / MGI
  • liver hypoplasia / MGI
  • decreased embryo size / MGI
  • absent ovary / MGI
  • hemopericardium / MGI
  • agonadal / MGI
  • absent testes / MGI
  • myocardium hypoplasia / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • absent metanephros / MGI
  • abnormal diaphragm development / MGI
  • abnormal heart apex morphology / MGI
  • abnormal adrenal gland development / MGI

Literature references

  • Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).;Patek Charles E, Brownstein David G, Fleming Stewart, Wroe Caroline, Rose Lorraine, Webb Anna, Berry Rachel L, Devenney Paul S, Walker Marion, Maddocks Oliver D K, Lawrence Nicola J, Harrison David J, Wood Katrina M, Miles Colin G, Hooper Martin L, ;2008;Transgenic research;17;459-75; 18040647

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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