B6.129S1(Cg)-Slc6a4tm1(tTA)Cogr/Cnrm

Status

Available to order

EMMA IDEM:04891
International strain nameB6.129S1(Cg)-Slc6a4tm1(tTA)Cogr/Cnrm
Alternative nameSERT-tTA
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolSlc6a4tm1(tTA)Cogr,
Gene/Transgene symbolSlc6a4

Information from provider

ProviderCornelius Gross
Provider affiliationMouse Biology Unit, European Molecular Biology Laboratory
Genetic informationA cassette containing the tetracycline trans-activator and a floxed neo were knocked into exon 2 at the translation initiation codon. In situ hybridization and autoradiography were used to confirm the absence of transcript and protein expression.
Phenotypic informationNo abnormal phenotype detected.
Breeding historyThe line was backcrossed in C57BL/6 for 12 generations and it is currently maintained by siblings breedings.
References
  • Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.;Audero Enrica, Coppi Elisabetta, Mlinar Boris, Rossetti Tiziana, Caprioli Antonio, Banchaabouchi Mumna Al, Corradetti Renato, Gross Cornelius, ;2008;Science (New York, N.Y.);321;130-3; 18599790
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

  • Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.;Audero Enrica, Coppi Elisabetta, Mlinar Boris, Rossetti Tiziana, Caprioli Antonio, Banchaabouchi Mumna Al, Corradetti Renato, Gross Cornelius, ;2008;Science (New York, N.Y.);321;130-3; 18599790

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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