strain-details - INFRAFRONTIER

Information from provider

Status	Available to order
EMMA ID	EM:04919
International strain name	C3HeB/FeJ-Crsl/IegWtsiCnbc
Alternative name	Carousel
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Crsl,
Gene/Transgene symbol	Crsl

Provider	Karen Steel
Provider affiliation	Wellcome Trust Sanger Institute
Additional owner	Prof. M. Hrabé de Angelis, Helmholtz Zentrum München, Neuherberg, Germany
Genetic information	ENU-induced mutation at proximal chromosome 4.
Phenotypic information	Circling, head-bobbing and hyperactive mutant, maps to proximal chromosome 4. Phenotype indistinguishable from Chd7 mutations.
Breeding history	Originated from ENU mutagenesis programme in Munich, Helmholtz Centrum, on a C3HeB/FeJ background and bred on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since.
References	Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4.;Hawker Kelvin, Fuchs Helmut, Angelis Martin Hrabéde, Steel Karen P, ;2005;International journal of audiology;44;171-7; 15916118
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Disease and phenotype information

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

MGI phenotypes (allele matching)

dry eyes / MGI
postnatal lethality / MGI
abnormal external female genitalia morphology / MGI
clitoris hypoplasia / MGI
keratoconjunctivitis sicca / MGI
circling / MGI
hyperactivity / MGI
head bobbing / MGI
abnormal superior semicircular canal morphology / MGI
absent lateral semicircular canal / MGI
decreased lateral semicircular canal size / MGI
increased cochlear inner hair cell number / MGI
increased cochlear outer hair cell number / MGI
abnormal round window morphology / MGI
abnormal stapes morphology / MGI
hearing/vestibular/ear phenotype / MGI
skeleton phenotype / MGI

Literature references

Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4.;Hawker Kelvin, Fuchs Helmut, Angelis Martin Hrabéde, Steel Karen P, ;2005;International journal of audiology;44;171-7; 15916118

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

C3HeB/FeJ-Crsl/IegWtsiCnbc

Information from provider

Information from EMMA

Disease and phenotype information

Literature references

Availabilities

Practical information

Other EMMA strains