C3HeB/FeJ-Fgfr1Hspy/IegWtsiCnbc

Status

Available to order

EMMA IDEM:04921
International strain nameC3HeB/FeJ-Fgfr1Hspy/IegWtsiCnbc
Alternative nameHushpuppy Fgfr1
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolFgfr1Hspy,
Gene/Transgene symbolFgfr1

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Additional ownerProf. M. Hrabé de Angelis, Helmholtz Zentrum München, Neuherberg, Germany
Genetic informationA new missense mutation induced by ENU in Fgfr1.
Phenotypic informationA new ENU-induced semi-dominant Fgfr1 mutation leading to pinna defects, middle ear ossicle malformations and mild skull anomalies in heterozygotes, with reduced penetrance. Homozygotes die in mid-gestation.
Breeding historyOriginated from ENU mutagenesis programme in Munich, Helmholtz Zentrum, on a C3HeB/FeJ background and bred on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since.
References
  • Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects.;Pau Henry, Fuchs Helmut, de Angelis Martin Hrabé, Steel Karen P, ;2005;The Laryngoscope;115;116-24; 15630379
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • small ears / MGI
  • abnormal snout morphology / MGI
  • short snout / MGI
  • abnormal outer ear morphology / MGI
  • abnormal incus morphology / MGI
  • abnormal stapes morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • abnormal ear shape / MGI
  • lowered ear position / MGI
  • abnormal inner ear morphology / MGI
  • abnormal middle ear morphology / MGI
  • short mandible / MGI
  • abnormal pinna reflex / MGI
  • increased susceptibility to otitis media / MGI
  • abnormal ear physiology / MGI
  • decreased cochlear outer hair cell number / MGI
  • decreased endocochlear potential / MGI
  • abnormal cochlear nerve compound action potential / MGI
  • short nasal bone / MGI
  • small cranium / MGI
  • abnormal incudostapedial joint morphology / MGI
  • abnormal auditory bulla morphology / MGI
  • abnormal incus short process morphology / MGI
  • abnormal incus long process morphology / MGI
  • absent incus lenticular process / MGI
  • abnormal incus body morphology / MGI
  • absent stapes head / MGI
  • abnormal stapes posterior crus morphology / MGI
  • small round window / MGI
  • absent round window / MGI
  • excessive cerumen / MGI
  • abnormal embryonic-extraembryonic boundary morphology / MGI
  • embryonic growth retardation / MGI
  • embryonic lethality between somite formation and embryo turning, complete penetrance / MGI

Literature references

  • Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects.;Pau Henry, Fuchs Helmut, de Angelis Martin Hrabé, Steel Karen P, ;2005;The Laryngoscope;115;116-24; 15630379

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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