- decreased body weight / IMPC
CBACa;129P2-Ube3bGt(RRJ142)Byg/WtsiCnbc
Status | Available to order |
EMMA ID | EM:04922 |
International strain name | CBACa;129P2-Ube3bGt(RRJ142)Byg/WtsiCnbc |
Alternative name | Ube3b genetrap |
Strain type | Gene-trap |
Allele/Transgene symbol | Ube3bGt(RRJ142)Byg, |
Gene/Transgene symbol | Ube3b |
Information from provider
Provider | Karen Steel |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | A genetrap from BayGenomics in the Ube3b gene. |
Phenotypic information | Homozygotes have reduced viability and show reduced body weight, reduced lipid levels, hot plate and grip strength anomalies (see Wellcome Trust Sanger Institute phenotyping data on web). |
Breeding history | Chimaeras from the 129P2 ES cells were mated with CBA/Ca and then the colony maintained by intercrossing. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Oculocerebrofacial syndrome, Kaufman type / Orphanet_2707
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- decreased circulating LDL cholesterol level / MGI
- decreased brain size / MGI
- decreased body weight / MGI
- decreased body size / MGI
- eye inflammation / MGI
- reduced fertility / MGI
- nervous system phenotype / MGI
- lymphangiectasis / MGI
- decreased circulating cholesterol level / MGI
- hearing/vestibular/ear phenotype / MGI
- calcified retina / MGI
- impaired hearing / MGI
- small hippocampus / MGI
- decreased grip strength / MGI
- preweaning lethality, incomplete penetrance / MGI
- decreased dentate gyrus size / MGI
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).