- decreased vertical activity / MGI
B6.Cg-Htr1atm2Rhn/Cnrm
Status | Available to order |
EMMA ID | EM:05004 |
International strain name | B6.Cg-Htr1atm2Rhn/Cnrm |
Alternative name | Htr1a-STOP-tetO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Htr1atm2Rhn, |
Gene/Transgene symbol | Htr1a |
Information from provider
Provider | Rene Hen |
Provider affiliation | Columbia University |
Additional owner | Dr Cornelius Gross |
Genetic information | Transcription of the coding region was blocked by the insertion of a neomycin resistance gene and tetO binding sites in the 5' untranslated region. |
Phenotypic information | Behavior/Neurological: homozygotes display behavioral despair and increased anxiety-related response. |
Breeding history | The line was backcrossed in C57BL/6J for 15 generations and it is currently maintained by sibling matings. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.;Gross Cornelius, Zhuang Xiaoxi, Stark Kimberly, Ramboz Sylvie, Oosting Ronald, Kirby Lynn, Santarelli Luca, Beck Sheryl, Hen René, ;2002;Nature;416;396-400; 11919622
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