C3HeB/FeJ-Mir96Dmdo/IegWtsiCnbc

Status

Available to order

EMMA IDEM:05010
International strain nameC3HeB/FeJ-Mir96Dmdo/IegWtsiCnbc
Alternative nameDiminuendo, Mir96
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolMir96Dmdo,
Gene/Transgene symbolMir96

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Additional ownerProf. M. Hrabé de Angelis, Helmholtz Zentrum München, Neuherberg, Germany
Genetic informationENU-induced mutation of Mir96.
Phenotypic informationHeterozygotes show progressive hearing loss and homozygotes have profound deafness from an early age with some balance defects.
Breeding historyOriginated from ENU mutagenesis programme in Munich, Helmholtz Centrum, on a C3HeB/FeJ background and bred on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since.
References
  • An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.;Lewis Morag A, Quint Elizabeth, Glazier Anne M, Fuchs Helmut, De Angelis Martin Hrabé, Langford Cordelia, van Dongen Stijn, Abreu-Goodger Cei, Piipari Matias, Redshaw Nick, Dalmay Tamas, Moreno-Pelayo Miguel Angel, Enright Anton J, Steel Karen P, ;2009;Nature genetics;41;614-8; 19363478
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • decreased body length / IMPC
  • decreased body weight / IMPC
  • abnormal cornea morphology / IMPC
  • hyperactivity / IMPC
  • abnormal gait / IMPC
  • abnormal startle reflex / IMPC
  • trunk curl / IMPC
  • increased thermal nociceptive threshold / IMPC
  • decreased circulating free fatty acid level / IMPC
  • abnormal bone mineralization / IMPC
  • abnormal bone structure / IMPC
  • increased lean body mass / IMPC
  • decreased lean body mass / IMPC
  • abnormal behavior / IMPC
  • increased total body fat amount / IMPC
  • decreased grip strength / IMPC
MGI phenotypes (allele matching)
  • abnormal pinna reflex / MGI
  • cochlear hair cell degeneration / MGI
  • cochlear outer hair cell degeneration / MGI
  • decreased cochlear nerve compound action potential / MGI
  • fused vestibular hair cell stereocilia / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • impaired hearing / MGI
  • circling / MGI
  • abnormal gait / MGI
  • head bobbing / MGI
  • deafness / MGI
  • decreased cochlear hair cell number / MGI
  • absent cochlear nerve compound action potential / MGI
  • absent pinna reflex / MGI

Literature references

  • An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.;Lewis Morag A, Quint Elizabeth, Glazier Anne M, Fuchs Helmut, De Angelis Martin Hrabé, Langford Cordelia, van Dongen Stijn, Abreu-Goodger Cei, Piipari Matias, Redshaw Nick, Dalmay Tamas, Moreno-Pelayo Miguel Angel, Enright Anton J, Steel Karen P, ;2009;Nature genetics;41;614-8; 19363478

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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