| Status | Available to order |
| EMMA ID | EM:05018 |
| International strain name | C3HeB/FeJ-Myo6Mhdatlc/IegWtsiCnbc |
| Alternative name | Tailchaser |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Myo6Mhdatlc, |
| Gene/Transgene symbol | Myo6 |
| Provider | Karen Steel |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Additional owner | Helmholtz Zentrum Muenchen carried out the mutagenesis and discovered the head-bobbing. |
| Genetic information | Sequencing of cDNA extracted and amplified from heterozygous brains revealed a c.G694T transversion in a region that corresponds to exon 6 of the gene. This mutation is predicted to result in an aspartic acid to tyrosine amino acid substitution at the highly conserved position 179 of the encoded protein. |
| Phenotypic information | Tlc/+ mutants display classic behavioural symptoms of a vestibular dysfunction, including head-shaking and circling. Behavioural testing of ageing mice revealed a gradual deterioration of both hearing and balance function, associated with hair bundle defects of sensory hair cells. Homozygotes are more severely affected. |
| Breeding history | Originated from ENU mutagenesis programme in Munich on a C3HeB/FeJ background and maintained on the same background within a closed colony or backcrossed to C3HeB/FeJ ever since. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Orphanet associated rare diseases, based on orthologous gene matching
