- impaired fertilization / MGI
- reduced male fertility / MGI
- decreased litter size / MGI
- asthenozoospermia / MGI
- impaired sperm capacitation / MGI
- transmission ratio distortion / MGI
- small ovary / MGI
- abnormal uterine cervix morphology / MGI
- decreased body weight / MGI
- postnatal growth retardation / MGI
- lung inflammation / MGI
- reduced female fertility / MGI
- delayed sexual maturation / MGI
- small uterus / MGI
- decreased corpora lutea number / MGI
- intestinal obstruction / MGI
- decreased ovulation rate / MGI
- abnormal sperm physiology / MGI
- abnormal phospholipid level / MGI
- decreased ovary weight / MGI
- decreased uterus weight / MGI
- homeostasis/metabolism phenotype / MGI
- prolonged estrous cycle / MGI
- absent estrous cycle / MGI
- thin uterus / MGI
- pancreatic acinar cell zymogen granule accumulation / MGI
- ileum hypertrophy / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- postnatal lethality, incomplete penetrance / MGI
- decreased respiratory epithelial chloride transmembrane transport / MGI
- decreased respiratory epithelial sodium ion transmembrane transport / MGI
- decreased intestinal epithelial sodium ion transmembrane transport / MGI
- pancreatic acinus dilation / MGI
- abnormal intestine morphology / MGI
- abnormal bronchus morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- pulmonary interstitial fibrosis / MGI
- increased lung compliance / MGI
- abnormal crypts of Lieberkuhn morphology / MGI
- abnormal colon morphology / MGI
- spleen hyperplasia / MGI
- decreased body size / MGI
- distended abdomen / MGI
- abnormal gait / MGI
- abnormal thymus involution / MGI
- female infertility / MGI
- abnormal pancreas morphology / MGI
- premature death / MGI
- abnormal gland morphology / MGI
- abnormal nasal mucosa morphology / MGI
- abnormal paranasal sinus morphology / MGI
- abnormal trachea morphology / MGI
- peritoneal inflammation / MGI
- abnormal submandibular gland morphology / MGI
- small pancreas / MGI
- abnormal gallbladder morphology / MGI
- dilated gallbladder / MGI
- coiled cecum / MGI
- increased respiratory mucosa goblet cell number / MGI
- abnormal Brunner's gland morphology / MGI
- abnormal trachea gland morphology / MGI
- abnormal intestinal goblet cell morphology / MGI
- decreased intestinal epithelial chloride transmembrane transport / MGI
- dilated crypts of Lieberkuhn / MGI
- abnormal vital capacity / MGI
- respiratory system phenotype / MGI
B6;129P2-Cftrtm1Unc/Orl
Status | Available to order |
EMMA ID | EM:00051 |
International strain name | B6;129P2-Cftrtm1Unc/Orl |
Alternative name | Cftr° |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cftrtm1Unc, |
Gene/Transgene symbol | Cftr |
Information from provider
Provider | Beverly H. Koller |
Provider affiliation | c/o CDTA-Orleans |
Phenotypic information | Mutant mice deficient in Cftr gene. Obtained by homologous recombination at exon 10 of the Cftr gene (insertion of the neomycin-resistance gene). No modification of the phenotype among the heterozygous population. Homozygotes show anomalies similar to human mucoviscidosis found in young patients. Most of these animals die of intestinal obstruction before mature age. |
Breeding history | 129/Ola ES cells; 3 generations of backcross to C57BL/6, then intercross. Breeding heterozygous x heterozygous. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous 129/Sv x C57BL/6, wild-type C57BL/6 |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Cystic fibrosis / Orphanet_586
- Congenital bilateral absence of vas deferens / Orphanet_48
MGI phenotypes (allele matching)
Literature references
- An animal model for cystic fibrosis made by gene targeting.;Snouwaert J N, Brigman K K, Latour A M, Malouf N N, Boucher R C, Smithies O, Koller B H, ;1992;Science (New York, N.Y.);257;1083-8; 1380723
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