MGI phenotypes (allele matching)
B6;129-Dcttm1(cre)Bee/Orl
| Status | Available to order |
| EMMA ID | EM:05144 |
| International strain name | B6;129-Dcttm1(cre)Bee/Orl |
| Alternative name | Dctko |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Dcttm1(cre)Bee, |
| Gene/Transgene symbol | Dct |
Information from provider
| Provider | Friedrich Beermann |
| Provider affiliation | EPFL SV ISREC |
| Genetic information | Knockout of the Dct gene. Exon 1 is replaced by a Cre recombinase cDNA and the PgkNeo cassette is still retained. |
| Phenotypic information | Slight coat color dilution in mice lacking Dct. |
| Breeding history | It was backcrossed 2-3 times to C57BL/6, and is kept as homozygous x homozygous matings. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Oculocutaneous albinism type 8 / Orphanet_597733
Literature references
- Expression of Cre recombinase in pigment cells.;Guyonneau Laurence, Rossier Anita, Richard Christelle, Hummler Edith, Beermann Friedrich, ;2002;Pigment cell research;15;305-9; 12100497
- Melanocytes and pigmentation are affected in dopachrome tautomerase knockout mice.;Guyonneau Laurence, Murisier Fabien, Rossier Anita, Moulin Alexandre, Beermann Friedrich, ;2004;Molecular and cellular biology;24;3396-403; 15060160
- Molecular characterization of melanocyte stem cells in their niche.;Osawa Masatake, Egawa Gyohei, Mak Siu-Shan, Moriyama Mariko, Freter Rasmus, Yonetani Saori, Beermann Friedrich, Nishikawa Shin-Ichi, ;2005;Development (Cambridge, England);132;5589-99; 16314490
- Elevated frequencies of self-reactive CD8+ T cells following immunization with a xenoantigen are due to the presence of a heteroclitic CD4+ T-cell helper epitope.;Kianizad Korosh, Marshall Laura A, Grinshtein Natalie, Bernard Dannie, Margl Renate, Cheng Sheng, Beermann Friedrich, Wan Yonghong, Bramson Jonathan, ;2007;Cancer research;67;6459-67; 17616707
- Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis.;Inoue-Narita Tae, Hamada Koichi, Sasaki Takehiko, Hatakeyama Sachiko, Fujita Sachiko, Kawahara Kohichi, Sasaki Masato, Kishimoto Hiroyuki, Eguchi Satoshi, Kojima Itaru, Beermann Friedrich, Kimura Tetsunori, Osawa Masatake, Itami Satoshi, Mak Tak Wah, Nakano Toru, Manabe Motomu, Suzuki Akira, ;2008;Cancer research;68;5760-8; 18632629
- Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers.;Levin Mark D, Lu Min Min, Petrenko Nataliya B, Hawkins Brian J, Gupta Tara H, Lang Deborah, Buckley Peter T, Jochems Jeanine, Liu Fang, Spurney Christopher F, Yuan Li J, Jacobson Jason T, Brown Christopher B, Huang Li, Beermann Friedrich, Margulies Kenneth B, Madesh Muniswamy, Eberwine James H, Epstein Jonathan A, Patel Vickas V, ;2009;The Journal of clinical investigation;119;3420-36; 19855129
- Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: implication for skin photoprotection against UVA radiation.;Jiang Shan, Liu Xiao-Ming, Dai Xin, Zhou Qiong, Lei Tie-Chi, Beermann Friedrich, Wakamatsu Kazumasa, Xu Shi-Zheng, ;2010;Free radical biology & medicine;48;1144-51; 20123016
- Key roles for transforming growth factor beta in melanocyte stem cell maintenance.;Nishimura Emi K, Suzuki Misa, Igras Vivien, Du Jinyan, Lonning Scott, Miyachi Yoshiki, Roes Jürgen, Beermann Friedrich, Fisher David E, ;2010;Cell stem cell;6;130-40; 20144786