B6;D2-Tg(Mlana-cre)5Bee/Orl
| Status | Available to order |
| EMMA ID | EM:05247 |
| International strain name | B6;D2-Tg(Mlana-cre)5Bee/Orl |
| Alternative name | Mart-1::Cre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Mlana-cre)5Bee, |
| Gene/Transgene symbol | Tg(Mlana-cre)5Bee |
Information from provider
| Provider | Friedrich Beermann |
| Provider affiliation | EPFL SV ISREC |
| Genetic information | A MART-1 BAC was modified by homologous recombination in bacteria and contains a Cre recombinase allowing for Cre recombinase expression driven by regulatory sequences of the MART-1/Mlana gene. |
| Phenotypic information | This is a Cre-expressing line which allows Cre expression in melanocytes and in the retinal pigment epithelium. |
| Breeding history | It is currently backcrossed to C57BL/6. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
Literature references
- A mart-1::Cre transgenic line induces recombination in melanocytes and retinal pigment epithelium.;Aydin Iraz T, Beermann Friedrich, ;2011;Genesis (New York, N.Y. : 2000);49;403-9; 21309074
- RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice.;Schouwey K, Aydin I T, Radtke F, Beermann F, ;2011;Oncogene;30;313-22; 20856205