C3H/HeOuJ-MaoaTg(H2-K1-Ifnb1)8Seif/Orl
| Status | Available to order |
| EMMA ID | EM:05408 |
| International strain name | C3H/HeOuJ-MaoaTg(H2-K1-Ifnb1)8Seif/Orl |
| Alternative name | MaoaTg(H2-K1-Ifnb1)8Seif or Tg 8 or MAOA KO |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | MaoaTg(H2-K1-Ifnb1)8Seif, |
| Gene/Transgene symbol | Maoa |
Information from provider
| Provider | Isabelle Seif |
| Provider affiliation | Neuropharmacologie, Faculte de pharmacie (Universite Paris-Sud) |
| Genetic information | These H2-IFNB transgenic mice have the coding region of the murine interferon beta 1 (Ifnb1) gene placed behind the proximal region of the promoter of the murine histocompatibility 2, K1, K region (H2-K1) gene. The transgene integrated into the X-linked monoamine oxidase A (Maoa) gene, replacing Maoa exons 2-3 and abolishing Maoa gene function. |
| Phenotypic information | These mice may be useful for studying MAOA-related aggression and abnormal development of neural circuits under excess serotonin. |
| Breeding history | brother/sister mating |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C3H/HeOuJ, wild-type C3H/HeOuJ |
| Breeding at archiving centre | Transgenic on X-chromosome. Hemizygous males have been crossed with wild-type females to obtain embryos. |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Monoamine oxidase A deficiency / Orphanet_3057
Literature references
- Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.;Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, Shih J C, ;1995;Science (New York, N.Y.);268;1763-6; 7792602