B6(Cg)-Grik4tm1.1(cre)Slab/H

Status

Available to order

EMMA IDEM:05449
International strain nameB6(Cg)-Grik4tm1.1(cre)Slab/H
Alternative nameKA1-Cre
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolGrik4tm1.1(cre)Slab,
Gene/Transgene symbolGrik4

Information from provider

ProviderRalf Schoepfer
Provider affiliationCBU, UCL
Genetic informationhttp://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=602859
Phenotypic informationCre recombinase-expressing mouse with restricted expression in subregions of the hippocampus, mainly in CA3 and absent in CA1. No obvious phenotype in the absence of a target allele.
Breeding historyOriginally produced from ES cells derived from C57BL/6NTacfBR, then backcrossed to C57BL/6J, then mated with a Flp deleter strain that was mainly C57BL/6J. Since then further backcrossed to C57BL/6J.
References
  • Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.;Filosa Alessandro, Paixão Sónia, Honsek Silke D, Carmona Maria A, Becker Lore, Feddersen Berend, Gaitanos Louise, Rudhard York, Schoepfer Ralf, Klopstock Thomas, Kullander Klas, Rose Christine R, Pasquale Elena B, Klein Rüdiger, ;2009;Nature neuroscience;12;1285-92; 19734893
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6J
Breeding at archiving centreMales were archived upon arrival at the archiving centre. No breeding was carried out.

Literature references

  • Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.;Filosa Alessandro, Paixão Sónia, Honsek Silke D, Carmona Maria A, Becker Lore, Feddersen Berend, Gaitanos Louise, Rudhard York, Schoepfer Ralf, Klopstock Thomas, Kullander Klas, Rose Christine R, Pasquale Elena B, Klein Rüdiger, ;2009;Nature neuroscience;12;1285-92; 19734893

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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