B6.Cg-Ifnar1tm1Agt Tg(Hmgcr-SLAMF1)1Hrvt/Orl

Status

Available to order

EMMA IDEM:05597
International strain nameB6.Cg-Ifnar1tm1Agt Tg(Hmgcr-SLAMF1)1Hrvt/Orl
Alternative nameSLAMxIFNAR KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIfnar1tm1Agt,
Gene/Transgene symbolIfnar1

Information from provider

ProviderBranka Horvat
Provider affiliationINSERM
Genetic informationMice are transgenic for the human receptor for measles virus CD150 (SLAM), crossed to the background of interferon alpha/beta receptor (Ifnar1) knock-out.
Phenotypic informationMice are highly susceptible to the intranasal measles virus infection and allow testing of the efficiency of mealses vaccines and anti-viral treatment.
Breeding historySLAM transgenic mice were crossed initially to the C57BL/6 background during 10 generations. This line was then crossed in the interferon receptor alpha/beta (Ifnar1) deficient background. Embryos and sperm have been obtained and frozen at PBES (Plateau de Biologie Expérimentale de la Souris Ecole Normale Superieure de Lyon) in Lyon.
References
  • Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.;Sellin Caroline I, Jégou Jean-François, Renneson Joëlle, Druelle Johan, Wild T Fabian, Marie Julien C, Horvat Branka, ;2009;PloS one;4;e4948; 19319188
  • High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice.;Sellin Caroline I, Davoust Nathalie, Guillaume Vanessa, Baas Dominique, Belin Marie-Françoise, Buckland Robin, Wild T Fabian, Horvat Branka, ;2006;Journal of virology;80;6420-9; 16775330
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedyes

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J, wild-type C57BL/6J
Breeding at archiving centreMales and females are homozygous knock-out for Ifnar1-tm1Agt; males and females are heterozygous for the Tg(Hmgcr-SLAMF1)1Hrvt (SLAM) transgene.

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased bone mineral density / MGI
  • increased tumor growth/size / MGI
  • abnormal osteoclast morphology / MGI
  • abnormal response to infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-alpha secretion / MGI
  • decreased interferon-beta secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal inflammatory response / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal immunoglobulin level / MGI
  • abnormal cytokine secretion / MGI
  • corneal vascularization / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • abnormal NK cell physiology / MGI
  • altered susceptibility to infection / MGI
  • immune system phenotype / MGI
  • abnormal CD8-positive, alpha-beta T cell physiology / MGI
  • abnormal interferon-gamma secretion / MGI
  • increased circulating interleukin-12 level / MGI

Literature references

  • Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.;Sellin Caroline I, Jégou Jean-François, Renneson Joëlle, Druelle Johan, Wild T Fabian, Marie Julien C, Horvat Branka, ;2009;PloS one;4;e4948; 19319188
  • High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice.;Sellin Caroline I, Davoust Nathalie, Guillaume Vanessa, Baas Dominique, Belin Marie-Françoise, Buckland Robin, Wild T Fabian, Horvat Branka, ;2006;Journal of virology;80;6420-9; 16775330

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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