STOCK Otx2tm1.1(cre/ERT2)Mgoe/Cnrm
| Status | Available to order |
| EMMA ID | EM:05640 |
| International strain name | STOCK Otx2tm1.1(cre/ERT2)Mgoe/Cnrm |
| Alternative name | Otx2-CreER |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Otx2tm1.1(cre/ERT2)Mgoe, |
| Gene/Transgene symbol | Otx2 |
Information from provider
| Provider | Antonio Simeone |
| Provider affiliation | Ceinge Biotecnologie Avanzate |
| Genetic information | The Otx2 allele is replaced with CreER gene by homologous recombination. |
| Phenotypic information | By 9.5 dpc, homozygous mutant embryos are characterized by the absence of forebrain and midbrain regions. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Combined pituitary hormone deficiencies, genetic forms / Orphanet_95494
- Butterfly-shaped pigment dystrophy / Orphanet_99001
- Colobomatous microphthalmia / Orphanet_98938
- Nanophthalmos / Orphanet_35612
- Syndromic microphthalmia type 5 / Orphanet_178364
- Septo-optic dysplasia spectrum / Orphanet_3157
Literature references
- The transcription factor Otx2 regulates choroid plexus development and function.;Johansson Pia A, Irmler Martin, Acampora Dario, Beckers Johannes, Simeone Antonio, Götz Magdalena, ;2013;Development (Cambridge, England);140;1055-66; 23364326