- decreased circulating LDL cholesterol level / IMPC
- decreased circulating HDL cholesterol level / IMPC
- abnormal cranium morphology / IMPC
- abnormal snout morphology / IMPC
- abnormal radius morphology / IMPC
- decreased body length / IMPC
- decreased body weight / IMPC
- abnormal tooth morphology / IMPC
- decreased circulating alanine transaminase level / IMPC
- decreased lean body mass / IMPC
- abnormal ulna morphology / IMPC
- decreased circulating cholesterol level / IMPC
- increased mean corpuscular hemoglobin / IMPC
- increased hemoglobin content / IMPC
- increased blood urea nitrogen level / IMPC
- decreased circulating aspartate transaminase level / IMPC
- decreased total body fat amount / IMPC
- decreased bone mineral content / IMPC
- preweaning lethality, incomplete penetrance / IMPC
B6Brd;B6N-Tyrc-Brd Ltbp1tm1a(EUCOMM)Wtsi/WtsiH
Status | Available to order |
EMMA ID | EM:05861 |
International strain name | B6Brd;B6N-Tyrc-Brd Ltbp1tm1a(EUCOMM)Wtsi/WtsiH |
Alternative name | EPD0127_1_A03 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Ltbp1tm1a(EUCOMM)Wtsi, |
Gene/Transgene symbol | Ltbp1 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0127_1_A03. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | heterozygous C57BL/6NTac |
Breeding at archiving centre | Received as frozen sperm. Due to the possible presence of C57BL/6Brd-Tyrc-Brd, albino pups might be produced by intercrossing. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive cutis laxa type 1 / Orphanet_90349
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- increased leukocyte cell number / MGI
- decreased circulating LDL cholesterol level / MGI
- decreased circulating HDL cholesterol level / MGI
- abnormal cranium morphology / MGI
- abnormal snout morphology / MGI
- abnormal radius morphology / MGI
- decreased body length / MGI
- decreased body weight / MGI
- abnormal tooth morphology / MGI
- decreased circulating alanine transaminase level / MGI
- decreased circulating iron level / MGI
- abnormal ulna morphology / MGI
- decreased circulating cholesterol level / MGI
- abnormal incisor morphology / MGI
- decreased circulating serum albumin level / MGI
- increased mean corpuscular hemoglobin / MGI
- increased hemoglobin content / MGI
- increased blood urea nitrogen level / MGI
- decreased circulating total protein level / MGI
- decreased circulating aspartate transaminase level / MGI
- decreased total body fat amount / MGI
- decreased bone mineral content / MGI
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