- abnormal cornea morphology / IMPC
- corneal opacity / IMPC
- increased startle reflex / IMPC
- decreased circulating triglyceride level / IMPC
- decreased circulating free fatty acid level / IMPC
- decreased hemoglobin content / IMPC
- increased circulating alkaline phosphatase level / IMPC
- vertebral fusion / IMPC
- decreased B cell number / IMPC
- decreased circulating glucose level / IMPC
- increased mean corpuscular hemoglobin concentration / IMPC
- impaired pupillary reflex / IMPC
- increased circulating iron level / IMPC
- increased blood uric acid level / IMPC
- preweaning lethality, complete penetrance / IMPC
B6Brd;B6N-Tyrc-Brd Asxl1tm1a(EUCOMM)Wtsi/WtsiH
Status | Available to order |
EMMA ID | EM:05867 |
International strain name | B6Brd;B6N-Tyrc-Brd Asxl1tm1a(EUCOMM)Wtsi/WtsiH |
Alternative name | EPD0080_1_D11 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Asxl1tm1a(EUCOMM)Wtsi, |
Gene/Transgene symbol | Asxl1 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0080_1_D11. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | heterozygous C57BL/6Brd-Tyrc-Brd or C57BL/6NTac |
Breeding at archiving centre | Received as frozen material. Due to the possible presence of C57BL/6Brd-Tyrc-Brd, may produce albino pups if intercrossed. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Systemic mastocytosis with associated hematologic neoplasm / Orphanet_98849
- Aggressive systemic mastocytosis / Orphanet_98850
- Bohring-Opitz syndrome / Orphanet_97297
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- decreased leukocyte cell number / MGI
- abnormal cornea morphology / MGI
- corneal opacity / MGI
- decreased hemoglobin content / MGI
- vertebral fusion / MGI
- decreased lumbar vertebrae number / MGI
- decreased circulating glucose level / MGI
- decreased mean corpuscular hemoglobin / MGI
- increased blood uric acid level / MGI
- increased sacral vertebrae number / MGI
- opacity of vitreous body / MGI
- eye opacity / MGI
- lethality, complete penetrance / MGI
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