C.129P2-Cx3cr1tm1Litt/Ieg

Status

Available to order

EMMA IDEM:00591
International strain nameC.129P2-Cx3cr1tm1Litt/Ieg
Alternative nameCX3CR1/GFP
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCx3cr1tm1Litt,
Gene/Transgene symbolCx3cr1

Information from provider

ProviderSteffen Jung
Provider affiliationThe Weizmann Institute of Science
Genetic informationThe mutant mice carry a targeted replacement of the Cx3cr1 chemokine receptor gene with an EGFP reporter gene (see Jung et al. MCB 2000).
Phenotypic informationThe mutant mice have no obvious defects.
References
  • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.;Jung S, Aliberti J, Graemmel P, Sunshine M J, Kreutzberg G W, Sher A, Littman D R, ;2000;Molecular and cellular biology;20;4106-14; 10805752

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI phenotypes (allele matching)
  • paresis / MGI
  • increased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • microgliosis / MGI
  • homeostasis/metabolism phenotype / MGI
  • paralysis / MGI
  • demyelination / MGI
  • brain inflammation / MGI
  • abnormal leukocyte physiology / MGI
  • increased neuron apoptosis / MGI
  • abnormal microglial cell physiology / MGI
  • abnormal vascular wound healing / MGI
  • immune system phenotype / MGI
  • abnormal vascular smooth muscle physiology / MGI
  • brainstem hemorrhage / MGI
  • decreased NK cell number / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal NK cell physiology / MGI
  • increased susceptibility to dopaminergic neuron neurotoxicity / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal small intestinal villus morphology / MGI
  • increased dendritic cell number / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • decreased monocyte cell number / MGI
  • abnormal retina morphology / MGI
  • nervous system phenotype / MGI
  • impaired macrophage chemotaxis / MGI
  • decreased susceptibility to kidney reperfusion injury / MGI
  • choroidal neovascularization / MGI

Literature references

  • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.;Jung S, Aliberti J, Graemmel P, Sunshine M J, Kreutzberg G W, Sher A, Littman D R, ;2000;Molecular and cellular biology;20;4106-14; 10805752

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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