STOCK B2mtm1Unc H2-Ab1tm1Doi Tg(Cd4-EGFP)1Lt Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl

Status

Available to order

EMMA IDEM:05922
International strain nameSTOCK B2mtm1Unc H2-Ab1tm1Doi Tg(Cd4-EGFP)1Lt Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl
Alternative nameSure-L1/CD4-EGFP
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolB2mtm1Unc,
Gene/Transgene symbolB2m

Information from provider

ProviderYu Chun LONE
Provider affiliationINSERM U1014
Genetic informationA transgenic construct containing an enhanced green florescent protein cDNA fused to the murine Cd4 promoter as described by Reifsnyder P. et al. (PubMed: 10570176) was injected into Sure-L1 (EM:01783) mouse eggs. Founder line was then mated to Sure-L1 mice until homozygous.
Phenotypic informationSure-L1/Cd4-EGFP
References
  • A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice.;Pajot Anthony, Michel Marie-Louise, Fazilleau Nicolas, Pancré Véronique, Auriault Claude, Ojcius David M, Lemonnier François A, Lone Yu-Chun, ;2004;European journal of immunology;34;3060-9; 15468058
  • A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo.;Manjunath N, Shankar P, Stockton B, Dubey P D, Lieberman J, von Andrian U H, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;13932-7; 10570176
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous 0, homozygous 0
Breeding at archiving centreTransgenic for CD4; homozygote KO for IAbeta, Rag2 and GammaC; heterozygote for Beta2m.
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased level of surface class I molecules / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG level / MGI
  • abnormal pancreas morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased IgM level / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased circulating serum albumin level / MGI
  • increased T-helper 1 cell number / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased susceptibility to infection induced morbidity/mortality / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal pancreatic beta cell morphology / MGI
  • abnormal T cell number / MGI
  • insulitis / MGI
  • abnormal neuron proliferation / MGI
  • abnormal immune system morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal immune system cell morphology / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • reduced fertility / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal B cell physiology / MGI
  • abnormal immune system organ morphology / MGI
  • abnormal cytokine secretion / MGI
  • decreased susceptibility to parasitic infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • abnormal lymph node cell ratio / MGI

Literature references

  • A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice.;Pajot Anthony, Michel Marie-Louise, Fazilleau Nicolas, Pancré Véronique, Auriault Claude, Ojcius David M, Lemonnier François A, Lone Yu-Chun, ;2004;European journal of immunology;34;3060-9; 15468058
  • A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo.;Manjunath N, Shankar P, Stockton B, Dubey P D, Lieberman J, von Andrian U H, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;13932-7; 10570176

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